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首页> 外文期刊>Life sciences >The effect of melatonin and structural analogues on the lipid peroxidation of triglycerides enriched in omega-3 polyunsaturated fatty acids.
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The effect of melatonin and structural analogues on the lipid peroxidation of triglycerides enriched in omega-3 polyunsaturated fatty acids.

机译：褪黑激素和结构类似物对富含omega-3多不饱和脂肪酸的甘油三酸酯脂质过氧化的影响。

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摘要

The lipid peroxidation of triglycerides enriched in polyunsaturated fatty acids was investigated by photoemission techniques and the TBARS assay. Butylated hydroxytoluene, 5-OH-tryptophan and N-acetylserotonin inhibited light emission and TBARS formation in a concentration dependent manner. However, it was enhanced in the presence of melatonin and 5-methoxytryptamine and was dependent on its concentration. The total relative luminic units were found to be lower in those systems incubated in the presence of butylated hydroxytoluene, N-acetylserotonin or 5-OH-tryptophan; this decreased proportionally to the concentration of the compound tested. The order of inhibition was 5-OH-tryptophan>N-acetylserotonin>butylated hydroxytoluene with the following IC50 values: 0.65, 6.5 and 9.0 mM respectively. The free-radical scavenging activity of the indole derivatives was also analyzed by the DPPH method, and the results indicate that 5-OH-tryptophan, and N-acetylserotonin exhibited a dose-dependent free-radical scavenging ability at all of the tested concentrations. Thus, at 10 microM concentration a decrease of 84.71% and 73.50% of initial DPPH was observed, compared to 51.00% of BHT. Melatonin and 5-methoxytriptamine decreased the initial concentration of DPPH only 1.85% and 5.0%, respectively. The possible formation of N(1)-acetyl-N(2) formyl-5-methoxykynuramine (AFMK) during lipid peroxidation of triglycerides enriched in PUFAs with cumene hydroperoxide in the presence of melatonin was also analyzed.
机译：通过光发射技术和TBARS分析研究了富含多不饱和脂肪酸的甘油三酸酯的脂质过氧化作用。丁基化羟基甲苯，5-OH-色氨酸和N-乙酰5-羟色胺以浓度依赖的方式抑制光发射和TBARS的形成。但是，它在褪黑激素和5-甲氧基色胺存在下会增强，并取决于其浓度。发现在丁基化羟基甲苯，N-乙酰5-羟色胺或5-OH-色氨酸存在下孵育的那些系统中，总的相对发光单位较低。这与所测试化合物的浓度成比例地降低。抑制顺序为5-OH-色氨酸> N-乙酰5-羟色胺>丁基化羟基甲苯，其IC50值分别为：0.65、6.5和9.0 mM。还通过DPPH方法分析了吲哚衍生物的自由基清除活性，结果表明5-OH-色氨酸和N-乙酰5-羟色胺在所有测试浓度下均表现出剂量依赖性的自由基清除能力。因此，在10 microM浓度下，观察到初始DPPH降低了84.71％和73.50％，而BHT降低了51.00％。褪黑素和5-甲氧基三乙胺分别将DPPH的初始浓度分别降低了1.85％和5.0％。还分析了在褪黑素存在下，富含异丙醇的过氧化异丙苯中富含PUFA的甘油三酸酯的脂质过氧化过程中，N（1）-乙酰基-N（2）甲酰基-5-甲氧基kyururamine（AFMK）的可能形成。

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