Aloe-emodin as antiproliferative and differentiating agent on human U937 monoblastic leukemia cells.

Tabolacci C; Oliverio S; Lentini A; Rossi S; Galbiati A; Montesano C; Mattioli P; Provenzano B; Facchiano F; Beninati S

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Aloe-emodin as antiproliferative and differentiating agent on human U937 monoblastic leukemia cells.

机译：芦荟大黄素作为人U937单核细胞白血病细胞的抗增殖和分化剂。

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AIMS: Aloe-emodin (AE), a plant derived anthraquinone, has been shown to have anticancer activity in various human cancer cell lines. We have recently reported that AE possesses a differentiative potential on melanoma cells. The purpose of this study was to investigate the possible modulation of defined markers of monocytic differentiation of AE on human U937 cell line. MAIN METHODS: U937 cells differentiation has been confirmed unequivocally by Griess and nitroblue tetrazolium reduction assays, protoporphyrin IX accumulation, expression of CD14 and CD11b surface antigens, phagocytic activity, migration and attachment ability. The effect on polyamine metabolism, apoptosis and cytokine production was also investigated. KEY FINDINGS: We showed that AE-treated U937 cells exhibit a noticeably rise in transglutaminase activity. This enhanced enzyme activity correlates with AE-induced growth arrest and differentiation to functionally mature monocytes. SIGNIFICANCE: Taken together, the results reported here show that AE can promote the macrophage differentiation of U937 cells, suggesting that this anthraquinone could be a potential candidate as a differentiation-inducing selective agent for therapeutic treatment of leukemia.

机译：目的：芦荟大黄素（AE）是一种植物来源的蒽醌，已显示在多种人类癌细胞系中具有抗癌活性。我们最近报道，AE在黑色素瘤细胞上具有分化潜能。这项研究的目的是研究人U937细胞系上AE的单核细胞分化的定义标记的可能的调制。主要方法：已通过Griess和硝基蓝四唑还原测定，原卟啉IX积累，CD14和CD11b表面抗原的表达，吞噬活性，迁移和附着能力明确证实了U937细胞的分化。还研究了对多胺代谢，细胞凋亡和细胞因子产生的影响。主要发现：我们显示，经AE处理的U937细胞的转谷氨酰胺酶活性显着提高。这种增强的酶活性与AE诱导的生长停滞和向功能成熟单核细胞的分化有关。综上所述，此处报道的结果表明，AE可以促进U937细胞的巨噬细胞分化，这表明该蒽醌可能作为诱导分化的选择性治疗白血病的候选药物。

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《Life sciences》 |2011年第22期|共9页
作者
Tabolacci C; Oliverio S; Lentini A; Rossi S; Galbiati A; Montesano C; Mattioli P; Provenzano B; Facchiano F; Beninati S;
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正文语种 eng
中图分类医药、卫生;
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1. Aloe-emodin as antiproliferative and differentiating agent on human U937 monoblastic leukemia cells. [J] . Tabolacci C, Oliverio S, Lentini A, Life sciences . 2011,第21a22期

机译：芦荟大黄素作为人U937单核细胞白血病细胞的抗增殖和分化剂。
2. Cytotoxicity and Apoptosis-Inducing Effect of Soybean Broth Cultured with Microorganisms Used in the Production of Fermented Soybean Foods on Human Monoblastic Leukemia U937 Cells [J] . Shyuichiro Inagaki, Takahiro Kato, Kuniyasu Ichige Food science and technology research . 2014,第2期

机译：微生物发酵大豆肉汤生产大豆食品对人单细胞白血病U937细胞的细胞毒性和诱导细胞凋亡的作用
3. Apoptosis Induction by Vinegar Produced from Boiled Extract of Black Soybeans in Human Monoblastic Leukemia U937 Cells: Difference in Sensitivity to Cell Toxicity Compared to Normal Lymphocytes [J] . Shyuichiro Inagaki, Shigeru Morimura, Toru Shigematsu, Food science and technology research . 2005,第3期

机译：黑豆水煮提取液中醋对人单细胞白血病U937细胞的凋亡诱导作用：与正常淋巴细胞相比，对细胞毒性的敏感性差异
4. Antiproliferative Effect of Fucoxanthin and Its Metabolites on Human Prostate Cancer Cells. [C] . International Symposium on the Efficient Application and Preservation of Marine Biological Resourecs; 20041029-1102; Qingdao(CN) . 2004

机译：岩藻黄质及其代谢产物对人前列腺癌细胞的抗增殖作用。
5. Characterization of gene expression profiles during differentiation, lipopolysaccharide stimulation, and heat shock repression in human U937 monocyte cells [D] . Kang, Susey H. 2004

机译：人U937单核细胞分化，脂多糖刺激和热休克抑制过程中基因表达谱的表征
6. Interferon-induced differentiation of U937 cells. Comparison with other agents that promote differentiation of human myeloid or monocytelike cell lines. [O] . T Hattori, M Pack, P Bougnoux, 1983

机译：干扰素诱导的U937细胞分化。与其他促进人骨髓或单核细胞样细胞系分化的药物的比较。
7. Interferon-induced differentiation of U937 cells. Comparison with other agents that promote differentiation of human myeloid or monocytelike cell lines. [O] . Hattori, T, Pack, M, Bougnoux, P, 1983

机译：干扰素诱导的U937细胞分化。与其他促进人骨髓或单核细胞样细胞系分化的药物的比较。

Aloe-emodin as antiproliferative and differentiating agent on human U937 monoblastic leukemia cells.

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