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首页> 外文期刊>Life sciences >The effect of isosteviol on hyperglycemia and dyslipidemia induced by lipotoxicity in rats fed with high-fat emulsion
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The effect of isosteviol on hyperglycemia and dyslipidemia induced by lipotoxicity in rats fed with high-fat emulsion

机译：异黄酮醇对高脂乳剂喂养大鼠脂中毒引起的高血糖和血脂异常的影响

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Aims: The aim of present study was to investigate the effects of isosteviol on hyperglycemia and hyperlipidemia in rats fed with high-fat emulsion (HFE). Main methods: Hyperglycemia and hyperlipidemia in rats was induced by daily ingestion of HFE for 14 days. Isosteviol (0.2, 1.0, or 5.0 mg/kg/day) was orally administered for 7 days, with rosiglitazone maleate (5.0 mg/kg/day) used as the positive control. The levels of fasting serum glucose (FSG), fasting serum insulin (FSI), total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), and low density lipoprotein (LDL) in serum were assayed. Intravenous glucose tolerance test (IVGTT) was performed with serum glucose and insulin levels monitored. The effect of the supplement of palmitate in HFE on the activity of isosteviol was investigated. Ultrastructural changes in islet β-cells and peroxisome proliferator-activated receptor α (PPARα) mRNA expression profile were determined. Key findings: FSG, FSI, TC and LDL levels and insulin resistance index (IRI) were decreased and HDL level was increased by all doses of isosteviol. During IVGTT, serum glucose levels were decreased by isosteviol and no significant differences were observed in insulin release between isosteviol-treated and control groups. The effects of isosteviol were attenuated by palmitate. Damage to pancreatic islet cells was partially attenuated, and expression profile of hepatic PPARα mRNA was enhanced by isosteviol. Significance: Antihyperglycemic effects of isosteviol could enhance utilization of glucose in the periphery and reduce β-cell damage induced by dyslipidemia. Modulating-lipidemic effects of isosteviol might be related to the potential enhancement of liver PPARα mRNA expression.
机译：目的：本研究的目的是研究异osteviol对高脂乳剂（HFE）喂养的大鼠高血糖和高脂血症的影响。主要方法：每天摄入HFE 14天可诱发大鼠高血糖和高血脂。口服异麦醇（0.2、1.0或5.0 mg / kg /天）持续7天，马来酸罗格列酮（5.0 mg / kg /天）用作阳性对照。测定血清中的空腹血清葡萄糖（FSG），空腹血清胰岛素（FSI），总胆固醇（TC），甘油三酸酯（TG），高密度脂蛋白（HDL）和低密度脂蛋白（LDL）的水平。进行静脉葡萄糖耐量试验（IVGTT），同时监测血清葡萄糖和胰岛素水平。研究了在HFE中补充棕榈酸酯对异雌甾醇活性的影响。测定了胰岛β细胞和过氧化物酶体增殖物激活的受体α（PPARα）mRNA表达谱的超微结构变化。关键发现：所有剂量的异黄酮醇均可降低FSG，FSI，TC和LDL水平以及胰岛素抵抗指数（IRI），而HDL水平升高。在IVGTT期间，异戊烯醇可降低血清葡萄糖水平，异戊醇治疗组与对照组之间的胰岛素释放无明显差异。棕榈酸酯减弱了异osteviol的作用。异戊四醇可部分减轻对胰岛细胞的损害，并增强肝PPARαmRNA的表达。意义：异雌烯醇的降血糖作用可以增强外周血葡萄糖的利用，减少血脂异常引起的β细胞损伤。异osteviol的调节血脂作用可能与肝脏PPARαmRNA表达的潜在增强有关。

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