• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Thermal, mechanical and chemical peripheral sensation in amphibians: opioid and adrenergic effects.
【24h】

Thermal, mechanical and chemical peripheral sensation in amphibians: opioid and adrenergic effects.

机译：两栖动物的热，机械和化学周围感觉：阿片类药物和肾上腺素能。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The acetic acid test (AAT) is a quantifiable assay of the response to noxious chemical stimuli on the hindlimb of the northern grass frog, Rana pipiens. AAT is sensitive to both opioid and adrenergic agonist modulation. The present study introduces the novel use of mechanical and thermal stimulus behavioral assays in comparison with the established acetic acid test in studying nociception in frogs. We evaluated mechanical and thermal responses and their sensitivity to systemic morphine (MOR) or dexmedetomidine (DEX) administrations with comparison to AAT. MOR produced dose-related elevations of response thresholds in all three sensory tests, whereas DEX produced elevations in the thermal and AAT assays but had no effect on sensitivity to non-noxious mechanical stimuli. The results suggest a distinct separation of sensory modalities in the frog similar to that observed in mammals and indicate the usefulness of this amphibian model in further studies of nociception.
机译：乙酸测试（AAT）是对北方草蛙（Rana pipiens）的后肢对有害化学刺激的反应的定量测定。 AAT对阿片样物质和肾上腺素能激动剂调制均敏感。本研究介绍了机械和热刺激行为测定法与已建立的乙酸测试法在研究青蛙伤害感受中的新颖用途。我们评估了机械和热反应以及它们对全身性吗啡（MOR）或右美托咪定（DEX）给药的敏感性，并与AAT进行了比较。在所有三种感觉测试中，MOR均使剂量的反应阈值升高，而在热和AAT分析中，DEX则使反应阈值升高，但对非有害机械刺激的敏感性没有影响。结果表明青蛙的感觉模态与哺乳动物中观察到的感觉模态明显不同，表明该两栖动物模型在伤害感受的进一步研究中很有用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号