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STUDIES OF WORKING MEMORY USING (18)FDG-POSITRON EMISSION TOMOGRAPHY IN NORMAL CONTROLS AND SUBJECTS WITH EPILEPSY

机译:(18)FDG-正电子发射断层显像在正常对照和癫痫患者中的工作记忆研究

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We have studied three groups of subjects with a working memory paradigm, using (18)FDG-PET. Controls show the greatest increase on uptake in dorsolateral prefrontal cortex, basal forebrain and angular gyrus. A group of subjects with focal frontal epilepsy did not show increases compared to a control task of attention. Primary generalized epilepsy subjects show the greatest changes in angular gyrus, dorsal temporal, medial frontal and parietal regions. Factor and regression analyses extend these observations and show reliance of both patient groups on the medial and inferior temporal lobe. We propose that the normal network of working memory is disrupted by these two forms of epilepsy and different networks are accessed. Declarative memory may be used as a compensatory system, which results in decreased performance. [References: 43]
机译:我们使用(18)FDG-PET研究了三组具有工作记忆范式的受试者。对照显示背外侧前额叶皮层,基底前脑和角回的摄取最大。与注意的控制任务相比,患有局灶性额叶癫痫的一组受试者没有显示出增加。原发性全身性癫痫患者在角回,颞背,额额内侧和顶叶区域的变化最大。因子分析和回归分析扩展了这些观察结果,并显示了两组患者均依赖于内侧和下部颞叶。我们建议正常的工作记忆网络被这两种形式的癫痫病破坏,并且可以访问不同的网络。声明式内存可用作补偿系统,这会导致性能降低。 [参考:43]

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