Age-related decrease of gamma-aminobutyric acid (GABA) release in brain of spontaneously hypertensive rats.

Ichida T; Takeda K; Sasaki S; Nakagawa M; Hashimoto T; Kuriyama K

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Age-related decrease of gamma-aminobutyric acid (GABA) release in brain of spontaneously hypertensive rats.

机译：自发性高血压大鼠脑内γ-氨基丁酸（GABA）释放的年龄相关性降低。

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We studied the developmental alteration of GABA release in spontaneous ly hypertensive(SHR) and normotensive Wistar-Kyoto rat(WKY) brain. The release of [3H]GABA observed under high potassium(30 mM) in eleven-week-old(hypertensive) SHR hippocampus and the spontaneous release of [3H]GABA in the same aged SHR medulla oblongata were lower than those of age-matched WKY. We conclude that the GABAergic mechanisms may be different in SHR and WKY brain and may be associated with the development of hypertension.

机译：我们研究了自发性高血压（SHR）和血压正常的Wistar-Kyoto大鼠（WKY）脑中GABA释放的发育变化。高钾（30 mM）下11周龄（高血压）SHR海马中观察到的[3H] GABA的释放和同一年龄的SHR延髓中[3H] GABA的自发释放均低于年龄相近的人WKY。我们得出的结论是，SHR和WKY脑中的GABA能机制可能不同，并且可能与高血压的发展有关。

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《Life sciences》 |1996年第3期|共7页
作者
Ichida T; Takeda K; Sasaki S; Nakagawa M; Hashimoto T; Kuriyama K;
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正文语种 eng
中图分类基础医学;
关键词
Hippocampus; Hypothalamus; Medulla Oblongata; gamma-Aminobutyric Acid; 海马; 下丘脑; 延髓;

机译：Hippocampus;Hypothalamus;Medulla Oblongata;gamma-Aminobutyric Acid;海马;下丘脑;延髓;

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1. Age-related decrease of gamma-aminobutyric acid (GABA) release in brain of spontaneously hypertensive rats. [J] . Ichida T, Takeda K, Sasaki S, Life sciences . 1996,第3期

机译：自发性高血压大鼠脑内γ-氨基丁酸（GABA）释放的年龄相关性降低。
2. Effects of increasing doses of vigabatrin on platelet gamma-aminobutyric acid-transaminase and brain gamma-aminobutyric acid in rats. [J] . Valdizan EM, Garcia AP, Armijo JA European Journal of Pharmacology: An International Journal . 1999,第2期

机译：Vigabatrin剂量增加对大鼠血小板γ-氨基丁酸转氨酶和脑γ-氨基丁酸的影响。
3. Role of the renal nerves in gamma-aminobutyric acid-induced antihypertensive effect in spontaneously hypertensive rats. [J] . Hayakawa K, Kimura M, Yamori Y European Journal of Pharmacology: An International Journal . 2005,第1a3期

机译：肾神经在自发性高血压大鼠中由γ-氨基丁酸诱导的降压作用中的作用。
4. Production of GABA-enriched Powder by Flammulina velutipes and Its Antihypertensive Effects in Spontaneously Hypertensive Rats [C] . Akira Harada, Takeshi Nagai, Miho Yamamoto Proceedings of the 18th congress of the International Society for Mushroom Science . 2012

机译：金针菇生产富含GABA的粉末及其对自发性高血压大鼠的降压作用
5. Modulation of gamma-aminobutyric acid (GABA) type A receptor-mediated responses in spinal dorsal horn neurons by mu-opioid receptor agonists and calcium(2+)/calmodulin-dependent protein kinase and Monte Carlo simulation of the GABAergic synaptic transmission. [D] . Wang, Rong. 1995

机译：γ-氨基丁酸（GABA）A型受体介导的mu阿片类受体激动剂和钙（2 +）/钙调蛋白依赖性蛋白激酶和Monte Carlo模拟的GABA能突触传递的脊髓背角神经元。
6. Tyrosine administration reduces blood pressure and enhances brain norepinephrine release in spontaneously hypertensive rats. [O] . A F Sved, J D Fernstrom, R J Wurtman 1979

机译：酪氨酸给药可降低自发性高血压大鼠的血压并增强其去甲肾上腺素的释放。
7. Tyrosine administration reduces blood pressure and enhances brain norepinephrine release in spontaneously hypertensive rats. [O] . Sved, A F, Fernstrom, J D, Wurtman, R J 1979

机译：酪氨酸给药可降低自发性高血压大鼠的血压，并增强其去甲肾上腺素的释放。
8. Inhibition of Transporter Mediated gamma-Aminobutyric Acid (GABA) Release by SKF 89976-A, a GABA Uptake Inhibitor, Studied in a Primary Neuronal Culture from Chicken. [R] . Lewin, L., Mattsson, M. O., Sellstroem, A. 1992

机译：通过sKF 89976-a释放转运蛋白介导的γ-氨基丁酸（GaBa）释放，sKF 89976-a是一种GaBa摄取抑制剂，在鸡的原代神经元培养物中进行研究。

Age-related decrease of gamma-aminobutyric acid (GABA) release in brain of spontaneously hypertensive rats.

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