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首页> 外文期刊>Life sciences >COMPARATIVE STUDY OF TOBORINONE (OPC-18790) AND MILRINONE ON ENERGY METABOLISM IN MICROEMBOLIZED GUINEA PIG HEARTS
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COMPARATIVE STUDY OF TOBORINONE (OPC-18790) AND MILRINONE ON ENERGY METABOLISM IN MICROEMBOLIZED GUINEA PIG HEARTS

机译：甲萘醌（OPC-18790）和美利农对微晶化几内亚猪心脏能量代谢的比较研究

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The effects of toborinone (OPC-18790) and milrinone on cardiac function and energetics were compared in microembolized guinea pig hearts. Male guinea pig hearts were perfused according to the Langendorff method and microembolization was induced by injecting microspheres. The hearts were then treated with toborinone (10 mu M), milrinone (4 mu M), and vehicle. Energy metabolism in hearts was assessed by 31-phosphorus magnetic resonance spectroscopy. (P-31-MRS). Microembolization produced a decrease in coronary perfusion flow (CPF), left ventricular developed pressure (LVP), and peak LVdP/dt by about 50% concomitantly with a decrease in creatine phosphate (PCr) and ATP and an increase in inorganic phosphate (Pi) and Pi/PCr ratio. Toborinone and milrinone increased peak LVdP/dt, an index of contractility, by 15 +/- 2% and 18 +/- 3%, respectively. Milrinone increased heart rate (HR) by 22 +/- 4% but toborinone did not change HR. Toborinone did not change PCr, ATP, Pi, Pi/PCr, and intracellular pH (pHi) compared with the vehicle. On the other hand, milrinone decreased PCr and increased Pi and Pi/PCr compared with toborinone or vehicle. These results suggest that the different effects between toborinone and milrinone on energy metabolism in microembolized hearts may be due to the difference of chronotropic action between these drugs. Thus toborinone, a positive inotropic agent without chronotropic action, may be effective in acute treatment of ischemic heart failure. [References: 18]
机译：在微栓塞的豚鼠心脏中比较了托硼利酮（OPC-18790）和米力农对心脏功能和能量的影响。根据Langendorff方法灌注雄性豚鼠心脏，并通过注射微球诱导微栓塞。然后将心脏用toborinone（10μM），milrinone（4μM）和媒介物处理。通过31磷磁共振波谱法评估心脏中的能量代谢。 （P-31-MRS）。微栓塞使冠状动脉灌注流量（CPF），左心室发育压力（LVP）和峰值LVdP / dt降低约50％，同时磷酸肌酸（PCr）和ATP降低，无机磷酸盐（Pi）升高和Pi / PCr比。托硼酮和米力农分别将峰值LVdP / dt（收缩指数）提高15 +/- 2％和18 +/- 3％。米力农可将心率（HR）提高22 +/- 4％，但托邦酮不会改变心率。与赋形剂相比，托硼酮不改变PCr，ATP，Pi，Pi / PCr和细胞内pH（pHi）。另一方面，与toborinone或赋形剂相比，milrinone降低PCr并增加Pi和Pi / PCr。这些结果表明，托邦酮和米力农之间对微栓塞心脏能量代谢的不同影响可能是由于这些药物之间的变时作用不同。因此，托硼利酮（一种无变时作用的正性肌力药）可有效治疗急性缺血性心力衰竭。 [参考：18]

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