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Long-term supplementation with a high cholesterol diet decreases the release of ATP from the caudal artery in aged rats.

机译:长期补充高胆固醇饮食可减少衰老大鼠尾动脉中ATP的释放。

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We examined the effects of high cholesterol (HC) diet on the spontaneous and noradrenaline-induced release of ATP, ADP, AMP and adenosine from caudal arteries and on the plasma levels of these adenyl purines in aged (100-week-old) Wistar rats. Administration of this diet for 12 weeks significantly reduced spontaneous and noradrenaline (1 micromol/L)-evoked release of adenyl purines from the caudal arteries relative to rats given the control diet The unsaturation index of fatty acids (UI), which gives the average number of double bonds, of both the plasma and the caudal artery was significantly less in the HC diet-fed rats than in those fed the control diet. The HC diet for 12 weeks produced a slight but significant increase in systolic and diastolic blood pressure with advancing age. Regression analysis revealed a significant inverse relationship between the total amount of purines released from the artery and diastolic blood pressure, and also a positive relationship between the total amount of purines released and the UI of the caudal artery. These results suggest that the high cholesterol diet decreased the release of adenyl purines from the caudal arteries of aged rats, leading to an increase in blood pressure.
机译:我们研究了高胆固醇饮食对衰老(100周龄)Wistar大鼠自发和去甲肾上腺素诱导的尾动脉ATP,ADP,AMP和腺苷释放以及这些腺嘌呤嘌呤血浆水平的影响。给予这种饮食12周,相对于给予对照饮食的大鼠,尾部动脉自发性和去甲肾上腺素(1 micromol / L)引起的腺嘌呤嘌呤的释放明显减少。脂肪酸的不饱和指数(UI),给出了平均值用HC饮食喂养的大鼠血浆和尾动脉的双键结合量显着低于用对照饮食喂养的大鼠。随着年龄的增长,连续12周的HC饮食可使收缩压和舒张压略微但显着升高。回归分析显示,从动脉释放的嘌呤总量与舒张压之间存在显着的负相关,而释放的嘌呤总量与尾动脉UI之间存在正相关。这些结果表明,高胆固醇饮食降低了老年大鼠尾动脉中腺嘌呤嘌呤的释放,从而导致血压升高。

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