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首页> 外文期刊>Life sciences >The awakening cortisol response and blood glucose levels.
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The awakening cortisol response and blood glucose levels.

机译：觉醒的皮质醇反应和血糖水平。

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The hypothalamic-pituitary-adrenal axis is characterized by a marked circadian cycle with heightened activity in the morning. This is synchronized to awakening such that free cortisol increases two to three fold in the first thirty to forty five minutes following awakening -- the awakening cortisol response. It has been suggested that this activity, by mobilizing energy reserves prepares the body for the metabolic demands of the day. Similar arguments are applied to the cortisol response to psychological challenge. Paradoxically the cortisol response to a psychosocial stressor is abrogated in fasted individuals with low blood glucose. Also cortisol response to a psychosocial stressor is positively correlated to blood glucose levels after glucose load. We examined if the same relationship applies to the awakening cortisol response. There was no correlation between the cortisol response and awakening blood glucose levels. Moreover a group with mean blood glucose at the bottom of the euglycemic range, identified by split at the median for glucose level upon awakening, showed no deficit in cortisol response. Hence the physiology of the awakening response differs to that of a psychological stress response. These data challenge the view that an oxidisable substrate for energy metabolism is permissive for cortisol responses. In addition the present findings do not support a predominantly gluconeogenic role for morning cortisol activation.
机译：下丘脑-垂体-肾上腺轴的特征在于昼夜节律周期明显，早晨活动增加。这与唤醒同步，因此在唤醒后的前三十到四十五分钟内，游离皮质醇增加了2到3倍-唤醒皮质醇的反应。已经提出，这种活动通过调动能量储备为身体做好了一天的代谢需求的准备。类似的论点也适用于皮质醇对心理挑战的反应。矛盾的是，低血糖的空腹个体对心理社会应激源的皮质醇反应消失了。而且，对社会心理压力源的皮质醇反应与葡萄糖负荷后的血糖水平呈正相关。我们检查了相同的关系是否适用于唤醒皮质醇反应。皮质醇反应与觉醒血糖水平之间没有相关性。此外，平均血糖在正常血糖范围底部的一组（通过唤醒后在中位血糖水平的分裂确定）表明，皮质醇反应无缺陷。因此，觉醒反应的生理学不同于心理应激反应的生理学。这些数据挑战了一种观点，即能量代谢的可氧化底物允许皮质醇反应。另外，本发现不支持早晨皮质醇活化的主要糖异生作用。

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