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首页> 外文期刊>Life sciences >Protection from hypoxemic renal dysfunction by verapamil and manganese in the rabbit.
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Protection from hypoxemic renal dysfunction by verapamil and manganese in the rabbit.

机译：维拉帕米和锰可防止家兔缺氧性肾功能不全。

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The ability of calcium channel blockers to prevent and/or to reverse the hypoxemia-induced renal dysfunction was studied in anesthetized and mechanically-ventilated rabbits. Renal blood flow (RBF) and glomerular filtration rate (GFR) were determined by para-aminohippuric acid and inulin clearance, respectively. Each animal was considered as its own control. In 9 rabbits (group 1), verapamil infusion, 1 microgram.kg-1.min-1, did not change basal renal hemodynamics. In a second group (n = 9), hypoxemia induced marked significant decreases in GFR, RBF and urine flow rate (-22 +/- 5%, -18 +/- 6% and -34 +/- 7% respectively). The administration of verapamil partially reversed the hypoxemia-induced renal dysfunction. Likewise, hypoxemia did not induce any change in renal function in verapamil pretreated rabbits (n = 8). This study shows that verapamil is able to prevent and to partially reverse the adverse effects of hypoxemia on renal hemodynamics. The intrarenal infusion of manganese chloride, another calcium channel blocker, was also effective in blunting the hypoxemia-induced changes in the left infused kidney, but not in the contralateral kidney. The overall results demonstrate that a significant protection from hypoxemic renal dysfunction can be achieved by inhibitors of calcium ion transport.
机译：在麻醉和机械通气的兔子中研究了钙通道阻滞剂预防和/或逆转低氧血症引起的肾功能障碍的能力。肾血流量（RBF）和肾小球滤过率（GFR）分别通过对氨基马尿酸和菊粉清除率确定。将每只动物视为其自己的对照。在9只兔子（第1组）中，维拉帕米1μg.kg-1.min-1的输注没有改变基础肾血流动力学。在第二组（n = 9）中，低氧血症引起的GFR，RBF和尿流率显着降低（分别为-22 +/- 5％，-18 +/- 6％和-34 +/- 7％）。维拉帕米的使用可部分逆转低氧血症引起的肾功能不全。同样，低氧血症在维拉帕米预处理的兔子中也不会引起肾功能的任何改变（n = 8）。这项研究表明维拉帕米能够预防并部分逆转低氧血症对肾脏血液动力学的不利影响。肾内输注氯化钙（另一种钙通道阻滞剂）也可有效抑制低氧血症引起的左输注肾脏的变化，但对侧肾脏无效。总体结果表明，通过钙离子转运抑制剂可以有效预防低氧血症性肾功能不全。

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