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首页> 外文期刊>Life sciences >NEUROPEPTIDE Y RECEPTOR SUBTYPES [Review]
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NEUROPEPTIDE Y RECEPTOR SUBTYPES [Review]

机译：神经肽Y受体亚型[综述]

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摘要

Neuropeptide Y (NPY) is an amidated 36-amino acid peptide with a wide distribution in the central and peripheral nervous system. It can evoke numerous physiological responses by activating specific receptors. Studies using NPY analogs in various model systems and cell types demonstrate different orders of ligand potency and receptor binding affinity. These studies suggest the existence of multiple subtypes of NPY receptors. NPY has been described to bind to at least three different receptors, Y-1, Y-2 and Y-3. NPY has also been shown to interact with sigma receptor in vivo and in vitro. There are indications that more subtypes might exist. Ligand binding studies reveal that Y-1, Y-2 and Y-3 receptors are all G-protein coupled. It is not yet confirmed whether the sigma receptor that interacts with NPY is G-protein coupled. Some studies show that NPY receptors may interact with other classical receptors, including alpha- and beta-adrenoceptors and cholinergic receptors. In the case of alpha- and beta-adrenoceptors, the receptor-receptor interaction is possibly via a pertussis toxin-sensitive G-protein. NPY receptors are coupled to various signal transduction mechanisms including inhibition of adenylate cyclase, and stimulation or inhibition of increases in intracellular Ca2+. Specific links between individual NPY receptor subtype and a particular signal transduction pathway are not established. [References: 79]
机译：神经肽Y（NPY）是一种酰胺化的36个氨基酸的肽，在中枢和周围神经系统中分布广泛。它可以通过激活特定的受体引起许多生理反应。在各种模型系统和细胞类型中使用NPY类似物进行的研究表明，配体效价和受体结合亲和力的顺序不同。这些研究表明存在多种NPY受体亚型。已经描述了NPY与至少三种不同的受体Y-1，Y-2和Y-3结合。 NPY还显示出在体内和体外与sigma受体相互作用。有迹象表明可能存在更多的子类型。配体结合研究表明，Y-1，Y-2和Y-3受体都是G蛋白偶联的。尚未确认与NPY相互作用的sigma受体是否是G蛋白偶联的。一些研究表明，NPY受体可能与其他经典受体相互作用，包括α和β肾上腺素受体和胆碱能受体。在α-和β-肾上腺素受体的情况下，受体-受体相互作用可能是通过百日咳毒素敏感的G蛋白。 NPY受体与各种信号转导机制偶联，包括抑制腺苷酸环化酶，以及刺激或抑制细胞内Ca2 +的增加。各个NPY受体亚型与特定信号转导途径之间的特定联系尚未建立。 [参考：79]

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