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首页> 外文期刊>Life sciences >Vascular adhesion molecule-1 and markers of platelet function before and after a treatment with iloprost or a supervised physical exercise program in patients with peripheral arterial disease
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Vascular adhesion molecule-1 and markers of platelet function before and after a treatment with iloprost or a supervised physical exercise program in patients with peripheral arterial disease

机译：伊洛前列素或有监督体育锻炼程序治疗周围动脉疾病患者前后的血管黏附分子-1和血小板功能标志物

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Platelet function and levels of vascular adhesion molecule-1 (VCAM-1) were investigated in 24 patients with peripheral arterial disease at Fontaine stage LI undergoing a 2 weeks treatment with iloprost (0.5-2 ng/kg/h i.v. infused, 6 h/day) or a 2 weeks supervised physical training, randomly assigned. Patients were studied before (T0) and after (T14) treatments and 10 days later (T24). The adhesion of washed platelets to fibrinogen coated microwells was reduced after treatment both with iloprost (1.9+/-0.4 vs 6.8+/-0.7 %; T24 vs T0; M+/-SEM; p<0.05) and physical exercise (3.0+/-1.0 vs 6.7+/-0.7; p<0.05) while adhesion to human plasma coated microwells was reduced only after treatment with iloprost (1.9+/-0.8 vs 5.8+/-0.9; p<0.05), The expression of fibrinogen receptor (glycoprotein IIb/IIIa) on platelets, measured by flow-cytometry was also reduced after iloprost treatment (17.1+/-1.5 vs 31.8+/-4.8 AU; p<0.05) and physical exercise (14.6 +/- 1.5 vs 34.0 +/- 3.3; p<0.05). The urinary excretion of platelet thromboxane A(2) metabolite 2,3-dinor-thromboxane B-2 decreased only in patients treated with iloprost (154.7+/-97.9 vs 256.2+/-106.4 pg mg creatinine(-1); p<0.05). Similarly plasma VCAM-1 was lower in patients who were treated with iloprost (827.7+/-77.4 vs 999.0+/-83.8 ng ml(-1); p<0.05). In conclusion, both iloprost and physical exercise seem to act on reversible phenomena such as the expression of adhesion molecules or ex vivo adhesion, whereas only iloprost reduces thromboxane A, biosynthesis in vivo. This anti-platelet activity seems to be extended in time and to be associated with an improvement in vascular function. (C) 2001 Elsevier Science Inc. All rights reserved. [References: 44]
机译：在接受伊洛前列素（0.5-2 ng / kg / h iv输注2 h，6小时/小时）的Fontaine分级为LI的24例外周动脉疾病患者中研究了血小板功能和血管粘附分子1（VCAM-1）的水平一天）或2周的有监督的体育锻炼，随机分配。在治疗之前（T0）和之后（T14）以及10天后（T24）对患者进行了研究。用伊洛前列素（1.9 +/- 0.4 vs 6.8 +/- 0.7％; T24 vs T0; M +/- SEM; p <0.05）和体育锻炼（3.0 + /）均能降低洗涤后的血小板与纤维蛋白原包被的微孔的粘附力-1.0 vs 6.7 +/- 0.7; p <0.05），而仅用伊洛前列素治疗后，与人血浆包被的微孔的粘附性降低（1.9 +/- 0.8 vs 5.8 +/- 0.9; p <0.05），纤维蛋白原受体的表达依洛前列素治疗（17.1 +/- 1.5 vs 31.8 +/- 4.8 AU; p <0.05）和体育锻炼（14.6 +/- 1.5 vs 34.0 +）后，通过流式细胞仪测量的血小板上的糖蛋白（糖蛋白IIb / IIIa）也降低了/-3.3; p <0.05）。仅伊洛前列素治疗的患者的血小板血栓素A（2）代谢产物2,3-二氮杂-血栓素B-2的尿排泄减少（154.7 +/- 97.9 vs 256.2 +/- 106.4 pg肌酐（-1）; p < 0.05）。类似地，接受伊洛前列素治疗的患者血浆VCAM-1较低（827.7 +/- 77.4 vs 999.0 +/- 83.8 ng ml（-1）; p <0.05）。总之，伊洛前列素和体育锻炼似乎都对可逆现象起作用，例如黏附分子的表达或离体黏附，而仅伊洛前列素可降低血栓烷A的体内生物合成。这种抗血小板活性似乎在时间上得以延长，并且与血管功能的改善有关。 （C）2001 Elsevier Science Inc.保留所有权利。 [参考：44]

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