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首页> 外文期刊>Life sciences >Activation of lung vagal sensory receptors by circulatory endotoxin in rats.
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Activation of lung vagal sensory receptors by circulatory endotoxin in rats.

机译：循环内毒素激活大鼠肺迷走感觉受体。

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Although endotoxin is known to induce various pulmonary responses that are linked to the function of lung vagal sensory receptors, its effects on these pulmonary receptors are still not clear. This study investigated the effects of circulatory endotoxin on the afferent activity of lung vagal sensory receptors in rats. We recorded afferent activity arising from vagal pulmonary C fibers (CFs), rapidly adapting receptors (RARs), tonic pulmonary stretch receptors (T-PSRs), and phasic pulmonary stretch receptors (P-PSRs) in 64 anesthetized, paralyzed, and artificially ventilated rats. Intravenous injection of endotoxin (50 mg/kg; lipopolysaccharide) stimulated 7 of the 8 CFs, 8 of the 8 RARs, and 4 of the 8 T-PSRs studied, while having no effect on the 8 P-PSRs tested. The stimulation started 3-16 min after endotoxin injection and lasted until the end of the 90-min observation period. The evoked discharge of either CFs or RARs was not in phase with the ventilatory cycle, whereas that of T-PSRs showed a respiratory modulation. Injection of a saline vehicle caused no significant change in the discharge of these receptors. Additionally, endotoxin significantly produced an increase in total lung resistance, and decreases in dynamic lung compliance and arterial blood pressure. Our results demonstrate that a majority of lung vagal sensory receptors are activated following intravenous injection of endotoxin, and support the notion that these pulmonary receptors may function as an important afferent system during endotoxemia.
机译：尽管已知内毒素会诱导多种与肺迷走神经感觉受体功能相关的肺部反应，但对这些肺部受体的作用仍不清楚。这项研究调查了循环内毒素对大鼠肺迷走感觉受体传入活性的影响。我们记录了64例麻醉，瘫痪和人工通气中的迷走性肺C纤维（CF），快速适应性受体（RAR），强直性肺舒张受体（T-PSR）和阶段性肺舒张受体（P-PSR）引起的传入活动。大鼠。静脉注射内毒素（50 mg / kg;脂多糖）刺激了所研究的8个CF中的7个，8个RAR中的8个和8个T-PSR中的4个，而对8个P-PSR没有影响。内毒素注射后3-16分钟开始刺激，一直持续到90分钟观察期结束。 CFs或RARs的诱发放电与通气周期不同，而T-PSRs则表现出呼吸调节。注射盐水载体不会导致这些受体的排出发生明显变化。此外，内毒素显着增加了总肺阻力，并降低了动态肺顺应性和动脉血压。我们的研究结果表明，静脉注射内毒素后，大部分肺迷走神经感觉受体被激活，并支持这些肺受体在内毒素血症期间可能作为重要的传入系统起作用的观点。

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