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Evaluation of the circadian profile of peripheral plasma galanin concentrations in normal subjects.

机译：正常受试者外周血浆甘丙肽浓度的昼夜节律评估。

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摘要

Galanin administration can influence pituitary function principally resulting in an increase in GH secretion. However, the role of circulating GAL levels in human endocrine function is still unknown. In the present study we simultaneously measured the circadian profiles of GAL, ACTH and GH in peripheral blood of ten adult subjects. Plasma samples were collected through an intravenous catheter at 0800, 1200, 1600, 2000, 2200, 2400, 0200, 0400 hours. The results were statistically evaluated by the cosinor analysis technique. A significant circadian rhythm of both plasma ACTH (p < 0.001) and GH levels (p < 0.03) was found with acrophases occurring at 0753 hrs and 0131 hrs for ACTH and GH, respectively. On the contrary, no significant rhythm was found in plasma GAL levels, indicating that no correlations exist between GAL and either GH or ACTH circadian profiles. Furthermore, the simultaneous assay of both GAL and GH plasma levels during a nocturnal frequent sampling performed in four volunteers showed the presence of peaks in GAL levels which, however, were not concomitant to the peaks in GH levels. These data demonstrate the lack of rhythmicity in the circadian profile of plasma GAL levels in healthy human subjects. The role of GAL in human endocrine function remains unknown and these results suggest that, in spite of the well documented increase in plasma GH concentrations following the intravenous administration of GAL, physiologically circulating levels of GAL are likely not involved in the regulation of GH secretion.
机译：甘丙肽的施用可主要影响垂体功能，导致GH分泌增加。但是，循环GAL水平在人类内分泌功能中的作用仍然未知。在本研究中，我们同时测量了十名成人受试者外周血中GAL，ACTH和GH的昼夜节律。在0800、1200、1600、2000、2200、2400、0200、0400小时通过静脉内导管收集血浆样品。通过余弦分析技术对结果进行统计评估。发现血浆ACTH（p <0.001）和GH水平（p <0.03）均存在明显的昼夜节律，其中促肾上腺皮质激素和GH的顶生相分别发生在0753和0131 hr。相反，在血浆GAL水平中未发现明显的节律，表明GAL与GH或ACTH昼夜节律谱之间不存在相关性。此外，在四名志愿者的夜间频繁采样过程中，同时检测GAL和GH血浆水平表明，GAL水平存在峰值，但与GH峰值不相关。这些数据表明健康人受试者血浆GAL水平的昼夜节律缺乏节律性。 GAL在人类内分泌功能中的作用仍然未知，这些结果表明，尽管在静脉内注射GAL后血浆GH浓度有充分记载，但GAL的生理循环水平可能不参与GH分泌的调节。

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