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首页> 外文期刊>Life sciences >The influence of ovariectomy and estrogen replacement on voiding patterns and detrusor muscarinic receptor affinity in the rat.
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The influence of ovariectomy and estrogen replacement on voiding patterns and detrusor muscarinic receptor affinity in the rat.

机译：卵巢切除术和雌激素替代对大鼠排尿模式和逼尿肌毒蕈碱受体亲和力的影响。

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A rat model of ovariectomy-induced voiding dysfunction was established and the effects of ovariectomy and subsequent estrogen replacement on the affinity of muscarinic receptors in the rat bladder were determined. Voiding frequency and spatial distribution patterns were documented in sham-operated (control), and ovariectomized (placebo- or estrogen-treated) rats. The ovariectomized rats had a significantly different urinating pattern, i.e. higher voiding frequency and less peripheral voiding than the sham-operated group, suggestive of urge incontinence. Using this model of voiding dysfunction, negative logs of dissociation constants of carbachol of the rat detrusor muscarinic receptors were then determined indirectly using the Furchgott's double-reciprocal method. Receptor affinities were not significantly different in all groups compared to control females. In conclusion, a model of ovariectomy-induced voiding dysfunction in ovariectomized rats was established, where bladder dysfunction occurred with no significant changes in the affinity of muscarinic receptors.
机译：建立了卵巢切除术引起的排尿功能障碍的大鼠模型，并确定了卵巢切除术和随后的雌激素替代对大鼠膀胱中毒蕈碱受体亲和力的影响。在假手术（对照）和去卵巢（安慰剂或雌激素治疗）大鼠中记录了呕吐频率和空间分布模式。去卵巢的大鼠排尿模式明显不同，即与假手术组相比，排尿频率较高，外周排尿较少，提示急迫性尿失禁。使用这种排尿功能障碍模型，然后使用Furchgott的双向可逆方法间接确定大鼠逼尿肌毒蕈碱受体的卡巴胆碱的解离常数。与对照组女性相比，所有组的受体亲和力没有显着差异。总之，建立了在卵巢切除的大鼠中卵巢切除术引起的排尿功能障碍的模型，其中发生了膀胱功能障碍，而毒蕈碱受体的亲和力没有明显变化。

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