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The effect of the selective 5-HT(3) receptor agonist on ferret gut motility.

机译：选择性5-HT（3）受体激动剂对雪貂肠道运动的影响。

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摘要

The effect of the selective 5-hydroxytryptamine (5-HT)(3) receptor agonist YM-31636 (2-(1H-imidazol-4-ylmethyl)-8H-indeno[1,2-d]thiazole monofumarate) on gut motility of fed ferrets was investigated. YM-31636 (0.1 mg/kg p.o.) induced a giant migrating contraction (GMC)-like, high-amplitude, ungrouped colonic contraction although it did not change the basal colonic motility pattern. This GMC-like contraction was always accompanied by defecation. Both GMC-like contraction and defecation were inhibited with the selective 5-HT(3) receptor antagonist ramosetron. YM-31636 affected gastric, duodenal and ileal motility pattern only slightly. These results suggest that 5-HT(3) receptor agonists such as YM-31636 are useful in treating constipation since they facilitate GMC-like contractions and defecation without undesired changes in gut motility pattern.
机译：选择性5-羟色胺（5-HT）（3）受体激动剂YM-31636（2-（1H-咪唑-4-基甲基）-8H-茚并[1,2-d]噻唑单富马酸酯）对肠道运动的影响进食雪貂的数量进行了调查。 YM-31636（0.1 mg / kg p.o.）诱导了巨大的迁移收缩（GMC）样，高幅度，无分组的结肠收缩，尽管它并没有改变基础结肠的运动模式。这种类似于GMC的收缩总是伴随着排便。选择性5-HT（3）受体拮抗剂雷莫司琼抑制了GMC样收缩和排便。 YM-31636仅轻微影响胃，十二指肠和回肠运动模式。这些结果表明，诸如YM-31636的5-HT（3）受体激动剂可用于治疗便秘，因为它们可促进GMC样的收缩和排便，而不会导致肠道蠕动模式发生不希望的变化。

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