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首页> 外文期刊>Life sciences >Enhanced inhibitory avoidance training protects against the amnesic effect of p-chloroamphetamine.
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Enhanced inhibitory avoidance training protects against the amnesic effect of p-chloroamphetamine.

机译：增强的抑制回避训练可防止对氯苯异丙胺的记忆删除。

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The contribution of acetylcholine (ACh) to memory processing is well documented, but it has been proposed that it is not necessary for memory consolidation after an enhanced learning experience. It has been suggested that serotonin (5-HT) interacts with ACh during memory consolidation, although the nature of this interaction is unknown in the case of strong learning. As an initial approach to the study of these interactions, we determined whether training of inhibitory avoidance using relatively high aversive stimulation protects against the typical retention deficits produced by pre-training administration of the 5-HT releaser p-chloroamphetamine (PCA). Rats were trained after intraperitoneal administration of PCA or isotonic saline, using 2.0, 2.5, 3.0 or 3.5 mA and retention of the task was measured 24 h later. A significant amnesic state was observed only in the PCA groups that had been trained with the two lower intensities. These results indicate that 5-HT systems behave similarly to ACh systems, in the sense that the amnesic effect produced by interference with their physiological activity may be cancelled when animals are submitted to an intense learning situation.
机译：乙酰胆碱（ACh）对记忆处理的贡献已有充分文献证明，但是已经提出，在增强学习体验之后，对于记忆巩固而言并不必要。有人提出，在记忆巩固过程中，5-羟色胺（5-HT）与ACh相互作用，尽管这种相互作用的本质在强学习的情况下是未知的。作为研究这些相互作用的一种初步方法，我们确定了使用相对较高的厌恶刺激来训练抑制性回避是否可以防止因5-HT释放剂对氯苯丙胺（PCA）的预训练给药而产生的典型保留缺陷。在腹膜内给予PCA或等渗盐水后，使用2.0、2.5、3.0或3.5 mA对大鼠进行训练，并在24小时后测量任务的保留时间。仅在接受过两种较低强度训练的PCA组中才观察到明显的记忆删除状态。这些结果表明，5-HT系统的行为类似于ACh系统，在某种意义上说，当动物处于强烈的学习环境中时，由于干扰其生理活动而产生的记忆消除作用可能会被抵消。

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