• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Enhanced cytotoxicity and suppression of glucose transport rate by combined treatment of recombinant human tumour necrosis factor-alpha and hyperthermia on L929 cells.
【24h】

Enhanced cytotoxicity and suppression of glucose transport rate by combined treatment of recombinant human tumour necrosis factor-alpha and hyperthermia on L929 cells.

机译：通过联合治疗重组人肿瘤坏死因子-α和热疗对L929细胞的增强的细胞毒性和葡萄糖转运速率的抑制。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Combined treatment with human recombinant TNF-alpha (rhTNF-alpha) and hyperthermia at 43 degrees C arrested the growth of mouse fibrosarcoma L929 cells in vitro. The cytotoxic effect was enhanced in combined treatment compared with that following administration of rhTNF-alpha or hyperthermia alone. When the cells were subjected to hyperthermia at 43 degrees C for 3 hours and then incubated with 0.4 ng/ml rhTNF-alpha at 37 degrees C for 24 hours, a statistically significant 65% decrease in the rate of cellular glucose uptake was observed. This suppressive effect was synergistic in terms of effect achieved by rhTNF-alpha or hyperthermia individually. Since the growth of tumour cells depends mainly on catabolism of glucose, our findings indicate that one manner by which combined rhTNF-alpha and hyperthermia treatment inhibits L929 cell growth may be by reducing the supply of glucose to the cells.
机译：与人重组TNF-α（rhTNF-alpha）和高温在43°C的联合治疗在体外抑制了小鼠纤维肉瘤L929细胞的生长。与单独施用rhTNF-α或热疗后相比，联合治疗的细胞毒性作用增强。当将细胞在43摄氏度下进行高温3小时，然后与0.4 ng / mlrhTNF-α在37摄氏度下孵育24小时时，观察到统计学上显着的细胞葡萄糖摄取率降低了65％。就单独通过rhTNF-α或高热所达到的效果而言，这种抑制作用是协同的。由于肿瘤细胞的生长主要取决于葡萄糖的分解代谢，因此我们的发现表明，rhTNF-α和高温疗法联合抑制L929细胞生长的一种方式可能是减少细胞中葡萄糖的供应。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号