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首页> 外文期刊>Life sciences >Dehydroepiandrosterone (DHEA)facilitates liver regeneration after partial hepatectomy in rats
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Dehydroepiandrosterone (DHEA)facilitates liver regeneration after partial hepatectomy in rats

机译：脱氢表雄酮（DHEA）促进大鼠部分肝切除术后的肝再生

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In this study we investigated whether or not liver regeneration is facilitated by dehydroepiandrosterone (DHEA) after partial (70%) hepatectomy in rats. Treatment with DHEA (300 mg/kg body weight) did not cause any significant increase in the expression ratio of proliferating cell nuclear antigen (PCNA) in sham-operated controls; however, in partially hepatectomized rats it caused a significant increase in the ratio in hepatocytes 24 and 36 hr after hepatectomy. In partially hepatectomized rats, DHEA treatment significantly accelerated the restoration of liver 48, 60, and 72 hr after partial hepatectomy. The restoration rate in DHEA-treated hepatectomized rats at 72 hr was 1.3-fold greater than in partially hepatectomized controls. Treatment with androstenedione (300 mg/kg body weight), the first metabolite of DHEA, did not cause any significant increase in the expression of PCNA in either sham-operated controls or partially hepatectomized rats. These results indicate that DHEA itself promotes the liver regenerative process after partial hepatectomy in rats.
机译：在这项研究中，我们调查了大鼠部分（70％）肝切除术后，脱氢表雄酮（DHEA）是否促进肝脏再生。在假手术对照组中，DHEA（300 mg / kg体重）治疗并未引起增殖细胞核抗原（PCNA）的表达比例显着增加。然而，在部分肝切除的大鼠中，它在肝切除后24和36小时引起肝细胞比例的显着增加。在部分切除肝的大鼠中，DHEA治疗显着加速了部分肝切除术后48、60和72小时的肝脏恢复。 DHEA处理的肝切除大鼠在72小时的恢复率比部分肝切除的对照组高1.3倍。在假手术对照组或部分肝切除的大鼠中，雄酮二酮（300 mg / kg体重）（DHEA的第一种代谢产物）治疗不会引起PCNA表达的任何显着增加。这些结果表明，DHEA本身可以促进大鼠部分肝切除术后的肝再生过程。

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