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首页> 外文期刊>Life sciences >Modulation of heme oxygenase in tissue injury and its implication in protection against gastrointestinal diseases.
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Modulation of heme oxygenase in tissue injury and its implication in protection against gastrointestinal diseases.

机译：血红素加氧酶在组织损伤中的调控及其对胃肠道疾病的保护作用。

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Heme oxygenase (HO) is the rate-limiting enzyme in the catabolism of heme, followed by production of biliverdin, free iron and carbon monoxide (CO). There are three isoforms of HO: HO-1 is highly inducible, whereas HO-2 and HO-3 are constitutively expressed. In addition to heme, a variety of nonheme compounds, including heavy metals, cytokines, endotoxins and heat shock stress are strong inducers of HO-1 expression. Many studies indicated that induction of HO-1 is associated with a protective response due to the removal of free heme, which is shown to be toxic. However, recent studies demonstrated that the expression of HO-1 in response to different inflammatory mediators could contribute in part to the resolution of inflammation and have protective effects on brain, liver, kidney and lung against injuries. These beneficial effects seem to be due to the production of bile pigment biliverdin and bilirubin that is a potent antioxidant, as well as the release of iron and CO. However, there are few studies concerning the relationship between HO-1 and inflammation as well as injury in the gut. Interestingly, a preliminary study implicated that induction of HO-1 expression in a colonic damage model induced by trinitrobenzene sulfonic acid played a critical protective role, indicating that activation of HO-1 could act as a natural defensive mechanism to alleviate inflammation and tissue injury in the gastrointestinal tract.
机译：血红素加氧酶（HO）是血红素分解代谢中的限速酶，其后产生胆绿素，游离铁和一氧化碳（CO）。 HO存在三种同工型：HO-1是高度诱导型的，而HO-2和HO-3是组成型表达的。除血红素外，多种非血红素化合物，包括重金属，细胞因子，内毒素和热休克应激也是HO-1表达的强诱导剂。许多研究表明，HO-1的诱导与保护性反应有关，这归因于游离血红素的清除，而后者被证明具有毒性。然而，最近的研究表明，HO-1响应不同的炎症介质的表达可能部分有助于炎症的消退，并且对脑，肝，肾和肺的损伤具有保护作用。这些有益的作用似乎是由于胆汁色素胆绿素和胆红素的产生（一种有效的抗氧化剂）以及铁和一氧化碳的释放引起的。但是，关于HO-1与炎症之间的关系以及相关研究很少。肠道受伤。有趣的是，一项初步研究表明，在三硝基苯磺酸诱导的结肠损伤模型中诱导HO-1表达起着关键的保护作用，表明HO-1的激活可以作为减轻炎症和组织损伤的天然防御机制。胃肠道。

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