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首页> 外文期刊>Life sciences >Low frequency flowmotion/(vasomotion) during patho-physiological conditions.
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Low frequency flowmotion/(vasomotion) during patho-physiological conditions.

机译：病理生理条件下的低频血流运动/（血管运动）。

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The role of low frequency flowmotion in physiological or pathophysiological settings is unclear.We performed various series of experiments in young anesthetized New Zealand white (NZW) rabbits. Many animals exhibited flowmotion during control conditions. However, they very often seemed to be in unstable physiological conditions, and our preset inclusion criteria (as to arterial pressure and blood gases) were frequently not met.Therefore, in a first series, we correlated these systematically with the incidence of flowmotion. Eleven of 35 anesthetized rabbits, subjected to extensive surgery, showed flowmotion with a median frequency of 1.5 cpm and a relative "amplitude" of 32%. Arterial pressure was 10 mmHg lower, bicarbonate, base-excess, and PCO(2) values and relative blood flow were also significantly lower compared to animals not exhibiting flowmotion.In a second series, we tested whether flowmotion could be induced by an isolated metabolic acidosis in animals meeting the inclusion criteria and not showing flowmotion at control. Here, flowmotion was induced in 9/10 cases (p < 0.01) 30 min after the start of an HCl-infusion.In a third study, we related the onset of flowmotion to the pressure/flow autoregulation curve. At locally reduced blood pressure all 23 rabbits exhibited flowmotion (p < 0,00001) in the gastrocnemius and the tenuissimus muscles, with maximum flowmotion at a locally reduced blood pressure of 30 mmHg; the LDF-flux level showing 67% of control flow.These results support the concept that low frequency periodic hemodynamics are a characteristic of pathophysiological conditions like hypoperfusion or acidosis rather than indicating a normal physiological state.
机译：低频血流运动在生理或病理生理环境中的作用尚不清楚。我们在麻醉的新西兰白兔中进行了一系列实验。在控制条件下，许多动物表现出血流运动。然而，它们似乎常常处于不稳定的生理状态，并且经常不符合我们预设的纳入标准（关于动脉压和血气）。因此，在第一个系列中，我们将这些与血流的发生率系统地关联起来。 35只麻醉兔子中，有11只接受了广泛的手术，其血流运动的中位频率为1.5 cpm，相对“振幅”为32％。与未表现出运动能力的动物相比，动脉压降低了10 mmHg，碳酸氢盐，碱过量和PCO（2）值以及相对血流也显着降低。在第二个系列中，我们测试了运动运动是否可以由孤立的代谢引起动物酸中毒符合纳入标准，且在对照组中未显示血流动力学。在此，在开始注入HCl 30分钟后的9/10例中，引起了运动运动（p <0.01）。在第三项研究中，我们将运动运动的发生与压力/流量自动调节曲线相关。在局部降低血压的情况下，所有23只兔子在腓肠肌和腱肌中均表现出血流运动（p <0,00001），在局部降低血压30 mmHg时表现出最大的血流运动。 LDF流量水平显示控制流量的67％。这些结果支持这样的概念，即低频周期性血液动力学是病理生理状况（例如灌注不足或酸中毒）的特征，而不是指示正常的生理状态。

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