• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Involvement of vanilloid receptor VR1 and prostanoids in the acid-induced writhing responses of mice.
【24h】

Involvement of vanilloid receptor VR1 and prostanoids in the acid-induced writhing responses of mice.

机译：香草酸受体VR1和类前列腺素参与酸诱导的小鼠扭体反应。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We found that intraperitoneal injection of organic acids, such as propionic and lactic acid, are able to develop writhing responses in mice similarly as that of acetic acid. These acid-induced writhing reactions were significantly attenuated by capsazepine, a VR1 receptor-specific antagonist, but the phenylbenzoquinone-induced one was not, suggesting that the acids but not phenylbenzoquinone activate the VR1 receptor, which is involved in polymodal pain perception. Hoe 140, a bradykinin B2 receptor antagonist, also suppressed the acid-induced writhing response. Furthermore, these writhing responses were significantly suppressed after neonatal treatment with capsaicin, which treatment is known to destroy peripheral sensory afferent C-fibers. Capsazepine and Hoe 140 did not further attenuate the already reduced writhing responses of capsaicin-treated mice, suggesting that the acids stimulate the VR1 and the bradykinin B2 receptor in the pathway comprising sensory afferent C-fibers. On the other hand, indomethacin further significantly suppressed the writhing number of the capsaicin-treated animals, suggesting that the acid-induced pain perception requires prostanoid receptors not only in the pathway via capsaicin-sensitive C-fibers but also in other sensory pathways. These results provide the first evidence for the involvement of the vanilloid receptor in the acid-induced inflammatory pain perception via sensory C-fibers in addition to the known mediators bradykinin, neurokinins, and prostanoids.
机译：我们发现腹膜内注射有机酸（例如丙酸和乳酸）与乙酸相似，能够在小鼠中产生扭体反应。这些酸诱导的扭体反应被VR1受体特异性拮抗剂Capsazepine显着减弱，但是苯苯醌诱导的扭体反应却没有，这表明酸而不是苯苯醌激活了VR1受体，而VR1受体参与了多峰性疼痛知觉。 Hoe 140，缓激肽B2受体拮抗剂，也抑制了酸诱导的扭体反应。此外，在使用辣椒素进行新生儿治疗后，这些扭动反应得到了显着抑制，已知该治疗会破坏周围的感觉传入C纤维。 Capsazepine和Hoe 140并没有进一步减弱已经用辣椒素处理过的小鼠的扭转反应，这表明酸在包含感觉传入C纤维的途径中刺激了VR1和缓激肽B2受体。另一方面，消炎痛进一步显着抑制了经辣椒素处理的动物的扭动数，这表明酸诱导的疼痛知觉不仅需要通过辣椒素敏感的C-纤维的途径中的前列腺素受体，而且还需要其他感觉途径。这些结果提供了除已知的缓激肽，神经激肽和类前列腺素外，类香草醛受体还通过感觉C纤维参与酸诱导的炎性疼痛知觉的第一个证据。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号