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首页> 外文期刊>Life sciences >Adhyperforin as a contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity.
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Adhyperforin as a contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity.

机译：肾上腺素在抗抑郁活性生化模型中对贯叶连翘的作用有贡献。

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The present paper describe investigations which demonstrate that hyperforin is not the only phloroglucinol derivative in extracts of the medicinal plant Hypericum perforatum L., which possess a biological activity. Hyperforin was the major lipophilic constituent in two different extracts, whereas the amount of adhyperforin was approximately 10 times lower. Adhyperforin, like hyperforin, is a potent inhibitor of the uptake of dopamine, serotonin and noradrenaline. Neither hyperforin nor adhyperforin inhibited binding of the cocaine analogue, [3H]WIN 35,428 to the dopamine transporter. However, the known antidepressives imipramine, nomifensine and fluoxetine all inhibited binding of [3H]WIN 35,428, indicating that hyperforin and adhyperforin do not bind to the same site on the dopamine transporter as these compounds. Furthermore, hyperforin and adhyperforin did not prevent dopamine binding, but inhibited dopamine translocation. Our studies further support recent reports suggesting that the effect of hyperforin on uptake of monoamines is probably not caused by a direct effect of hyperforin on known sites on the transporters.
机译：本论文描述了一些研究，这些研究表明，高通素不是药用植物贯叶连翘的提取物中唯一的间苯三酚衍生物，其具有生物活性。 Hyperforin是两种不同提取物中的主要亲脂性成分，而adhyperforin的含量大约低10倍。像高forin一样，hyperforforin是有效吸收多巴胺，5-羟色胺和去甲肾上腺素的抑制剂。 Hyperforin和Adhyperforin均不能抑制可卡因类似物[3H] WIN 35,428与多巴胺转运蛋白的结合。但是，已知的抗抑郁药丙咪嗪，诺米芬新和氟西汀均抑制[3H] WIN 35,428的结合，这表明高forin和adhyperforin与这些化合物在多巴胺转运蛋白上的结合位点不同。此外，hyperforin和adhyperforin不会阻止多巴胺结合，但会抑制多巴胺转运。我们的研究进一步支持了最近的报告，这些报告表明，hyperforin对单胺摄取的影响可能不是由hyperforin对转运蛋白已知位点的直接作用引起的。

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