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首页> 外文期刊>Life sciences >Prior exposure to methylenedioxyamphetamine (MDA) induces serotonergic loss and changes in spontaneous exploratory and amphetamine-induced behaviors in rats.
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Prior exposure to methylenedioxyamphetamine (MDA) induces serotonergic loss and changes in spontaneous exploratory and amphetamine-induced behaviors in rats.

机译：事先暴露于亚甲二氧基苯丙胺（MDA）会引起血清素能丧失以及大鼠自发探索性和苯丙胺诱导的行为变化。

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摘要

The substituted amphetamine 3,4 methylenedioxyamphetamine (MDA) is a popular recreational drug of abuse. Administration of MDA to experimental animals has been shown to induce damage to serotonergic axons and nerve terminals. However, there is a lack of information on whether these treatments can produce any long-term changes in behavioural performance particularly under stressful conditions. In the present study, MDA (7.5 mg/kg; i.p.) was administered twice daily to adult male Sprague Dawley rats for four days. Four weeks following the last dose, spontaneous behaviors of these animals were tracked and scored in a novel "open field" environment using an automated video registration and computer interpretation system. Changes in behavior were observed in MDA treated animals including reductions in exploratory oriented behaviors (locomotion and rearing) and increases in grooming behavior when compared to vehicle treated controls. MDA-treated animals also displayed an enhanced locomotor and stereotyped response to d-amphetamine (12 mg/kg; i.p.). Significant reductions in 5-HT concentrations (20-30%) were observed in the frontal cortex, amygdala, striatum, and hypothalamus as a result of MDA treatment. In addition, [3H] paroxetine binding was reduced by (40%) in the cortex of MDA treated rats indicating that the decrease in 5-HT concentrations were accompanied by a reduction in intact presynaptic 5-HT nerve terminals. Changes in behavioural performance in a novel "open field" environment and following d-amphetamine challenge might be considered as a behavioural model of serotonergic deficit induced by MDA. The findings of this study also suggest that MDA use may increase both the abuse potential, and the propensity to develop psychosis as a result of abusing other psychostimulants such as d-amphetamine.
机译：取代的苯丙胺3,4亚甲二氧基苯丙胺（MDA）是一种流行的娱乐性滥用药物。已证明对实验动物施用MDA会诱导对血清素能轴突和神经末梢的损害。但是，缺乏关于这些疗法是否能够在行为表现上产生任何长期变化的信息，特别是在压力条件下。在本研究中，每天对成年雄性Sprague Dawley大鼠进行两次MDA（7.5 mg / kg; i.p.）给药，持续4天。在最后一次给药后四周，使用自动视频注册和计算机解释系统，在新颖的“开阔地”环境中对这些动物的自发行为进行跟踪和评分。与媒介物处理的对照组相比，在接受MDA处理的动物中观察到行为变化，包括探索性行为减少（运动和饲养），修饰行为增加。用MDA处理的动物对d-苯异丙胺（12 mg / kg; i.p.）的运动和定型反应也增强。通过MDA治疗，额叶皮层，杏仁核，纹状体和下丘脑中的5-HT浓度显着降低（20-30％）。另外，在MDA处理的大鼠的皮质中，[3 H]帕罗西汀的结合减少了（40％），这表明5-HT浓度的降低伴随着完整的突触前5-HT神经末梢的减少。在新的“开放领域”环境中行为表现的变化以及继d-苯异丙胺攻击后，可以认为是MDA引起的血清素能缺乏症的行为模型。这项研究的发现还表明，使用MDA可能会增加滥用的可能性，并会因滥用其他精神兴奋剂（如d-苯异丙胺）而增加患上精神病的倾向。

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