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2,4,5-Trichlorophenoxyacetic acid inhibits apoptosis in PC12 cells

机译：2,4,5-三氯苯氧基乙酸抑制PC12细胞凋亡

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2,4,5-Trichlorophenoxyacetic acid (2,4,5-T) is an endocrine disrupter that exerts cytotoxic effects on organisms. In this study, the influence of 2,4,5-T at low concentrations on apoptosis in PC12 cells was investigated. Although no apoptotic features were observed in PC12 cells treated with 2,4,5-T, it inhibited the DNA fragmentation induced by serum deprivation. In addition, the cell viability of PC12 cells increased after treatment with 2,4,5-T. In conclusion, 2,4,5-T suppressed the apoptosis of the cultured cells. Since apoptosis is a morphological and biochemical description of a physiological mechanism of cell death that is commonly associated with programmed events necessary for development of individuals and organs, the inhibitory effect of 2,4,5-T on apoptosis might cause serious damage to cell homeostasis and differentiation. (C) 2001 Elsevier Science Inc. All rights reserved. [References: 21]
机译：2,4,5-三氯苯氧基乙酸（2,4,5-T）是一种内分泌干扰物，对生物体具有细胞毒性作用。在这项研究中，研究了低浓度的2,4,5-T对PC12细胞凋亡的影响。尽管在用2,4,5-T处理的PC12细胞中未观察到凋亡特征，但它抑制了血清剥夺诱导的DNA片段化。另外，用2,4,5-T处理后，PC12细胞的细胞活力增加。总之，2,4,5-T抑制了培养细胞的凋亡。由于凋亡是细胞死亡的生理机制的形态学和生化描述，通常与个体和器官发育所必需的程序性事件有关，因此2,4,5-T对凋亡的抑制作用可能会严重破坏细胞稳态和差异化。 （C）2001 Elsevier Science Inc.保留所有权利。 [参考：21]

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