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Reduced beta 2-receptor mediated vasodilation in African Americans.

机译:非裔美国人中β2受体介导的血管舒张减少。

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It is well recognized that African Americans have a higher prevalence of cardiovascular disease than White Americans although the underlying mechanisms are not entirely understood. This study was perfumed to evaluate racial differences in the chronotropic and vasodilatory effects of the beta-receptor agonist, isoproterenol. We compared cardiovascular responses to intravenous infusion of isoproterenol in 27 African Americans and 27 White men and women. African Americans showed significantly smaller beta 2-receptor mediated falls in diastolic pressure than Whites. In contrast, isoproterenol produced similar increases in heart rate in both races. The findings suggest that African Americans have decreased beta 2-receptor mediated vasodilatory capacity, and may help explain the higher prevalence of hypertension and cardiovascular disease in African Americans compared to Whites.
机译:众所周知,非洲裔美国人的心血管疾病患病率比白人美国人高,尽管其潜在机制尚不完全清楚。这项研究旨在评估β受体激动剂异丙肾上腺素在变时和血管舒张作用方面的种族差异。我们在27位非洲裔美国人和27位白人中比较了静脉注射异丙肾上腺素对心血管的反应。与白人相比,非裔美国人的舒张压下降幅度明显较小。相反,在两个种族中,异丙肾上腺素都会产生类似的心率增加。研究结果表明,非洲裔美国人的β2受体介导的血管舒张能力下降,这可能有助于解释非洲裔美国人与白人相比高血压和心血管疾病的患病率更高。

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