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首页> 外文期刊>Life sciences >SODIUM PIVALATE REDUCES CARDIAC CARNITINE CONTENT AND INCREASES GLUCOSE OXIDATION WITHOUT AFFECTING CARDIAC FUNCTIONAL CAPACITY
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SODIUM PIVALATE REDUCES CARDIAC CARNITINE CONTENT AND INCREASES GLUCOSE OXIDATION WITHOUT AFFECTING CARDIAC FUNCTIONAL CAPACITY

机译：戊二酸钠降低心脏的肉碱含量并增加葡萄糖氧化，而不会影响心脏的功能能力

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This study determined how selected cardiac functional, metabolic, and contractile properties were impacted by sodium pivalate, a compound which creates a secondary carnitine deficiency. Young male rats received either sodium pivalate (20 mM, PIV) or sodium bicarbonate (20mM, CONTR) in their drinking water. After 11-12 weeks cardiac function and glucose oxidation rates were measured in isolated, perfused working heart preparations. Hearts were also analyzed for carnitine content; activities of hexokinase (HK), citrate synthase (CS), and B-hydroxyacyl CoA dehydrogenase (HOAD); and myosin isoenzyme distribution. Sodium pivalate treatment significantly reduced cardiac carnitine content and increased glucose oxidation but did not alter cardiac functional capacity. HK activity was increased in the PIV group (p < 0.05), and HOAD activity decreased (p < 0.05). CS activity and myosin isoform distribution (V1 > 85%) remained unchanged. These results demonstrate that pivalate treatment of this duration and the accompanying carnitine deficiency shifts cardiac substrate utilization without compromising cardiac functional capacity. [References: 29]
机译：这项研究确定了特戊酸钠（一种会引起继发性肉碱缺乏的化合物）如何影响选定的心脏功能，代谢和收缩特性。幼小雄性大鼠的饮用水中含有新戊酸钠（20 mM，PIV）或碳酸氢钠（20mM，CONTR）。 11-12周后，在离体的灌注心脏工作制剂中测量心脏功能和葡萄糖氧化率。还分析了心脏的肉碱含量;己糖激酶（HK），柠檬酸合酶（CS）和B-羟酰基辅酶A脱氢酶（HOAD）的活性;和肌球蛋白同工酶分布。新戊酸钠治疗可显着降低心脏肉碱含量并增加葡萄糖氧化，但不会改变心脏功能。 PIV组HK活性增加（p <0.05），而HOAD活性降低（p <0.05）。 CS活性和肌球蛋白同工型分布（V1> 85％）保持不变。这些结果表明，在此期间进行新戊酸治疗以及伴随的肉碱缺乏，可以在不损害心脏功能能力的情况下改变心脏底物的利用率。 [参考：29]

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