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首页> 外文期刊>Life sciences >MODULATION OF ALPHA(1)-ADRENERGIC CONTRACTILITY IN ISOLATED VASCULAR TISSUES BY HEPTANOL - A FUNCTIONAL DEMONSTRATION OF THE POTENTIAL IMPORTANCE OF INTERCELLULAR COMMUNICATION TO VASCULAR RESPONSE GENERATION [Review]
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MODULATION OF ALPHA(1)-ADRENERGIC CONTRACTILITY IN ISOLATED VASCULAR TISSUES BY HEPTANOL - A FUNCTIONAL DEMONSTRATION OF THE POTENTIAL IMPORTANCE OF INTERCELLULAR COMMUNICATION TO VASCULAR RESPONSE GENERATION [Review]

机译：庚醇对孤立血管组织中α（1）-肾上腺收缩的调节作用-功能性证明细胞间通讯对血管生成的潜在重要性[综述]

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After years of intensive investigation, the mechanism(s) underlying syncytial vascular smooth muscle responses both in vitro and in vivo is still poorly understood. Neither perivascular innervation nor regenerative electrical events appear sufficient to coordinate responses among vascular smooth muscle cells in many blood vessels. The implication of these observations is that another mechanism is required for organizing syncytial vascular responses. Although gap junctions are ubiquitously distributed among vascular wall cells throughout the vascular tree, their contribution to the modulation of vasomotor tone is still considered controversial. Resolution of the long standing debate awaits a clear demonstration that gap junctions modulate contraction or relaxation responses of vascular smooth muscle. Despite the absence of specific gap junctional uncoupling agents, it has still been possible to identify reasonable experimental conditions under which the contribution of gap junctions to contractile responses in isolated vascular tissues could be evaluated. Studies in isolated preparations known to contain gap junctions have indicated that alpha(1)-adrenergic receptor-mediated contractile responses of diverse isolated vascular tissues, are significantly modulated by selective disruption of intercellular communication with the well studied lipophilic uncoupling agent heptanol. Interpretation of these pharmacological studies is explicitly dependent on the selectivity of the uncoupling actions of heptanol. Considerable experimental evidence suggests that, at the concentrations used, in the preparations thus far examined, heptanol does indeed have selective uncoupling actions. In fact, recent experiments provide empirical support for an operational definition of the selectivity of heptanol, and a functional role for gap junctions in modulating contractile responses in isolated vascular tissues. The operational definition states only that there exists a narrow, albeit identifiable, concentration range over which it is reasonable to assume that the effects of heptanol are primarily related to its uncoupling actions on gap junctions. The functional role for gap junctions is defined by their requisite contribution to tension development during contraction of isolated tissues. Experimentally, this can be visualized as significant diminution in the contractile responses of isolated vascular tissues in the presence of selective uncoupling heptanol concentrations. Thus, a cogent interpretation of available data is that they provide compelling indirect evidence for a principal role of gap junctions in modulating the alpha(1)-adrenergic contractility of isolated vascular tissues. [References: 49]
机译：经过多年的深入研究，对体内和体外合胞血管平滑肌反应的潜在机制仍知之甚少。血管周围神经支配或再生电事件似乎都不足以协调许多血管中血管平滑肌细胞之间的反应。这些观察结果的含义是组织合胞体血管反应需要另一种机制。尽管间隙连接普遍存在于整个血管树的血管壁细胞之间，但它们对调节血管舒缩张力的作用仍被认为是有争议的。长期辩论的解决有待明确表明，间隙连接调节血管平滑肌的收缩或松弛反应。尽管没有特定的间隙连接解偶联剂，但仍然有可能确定合理的实验条件，在该条件下可以评估间隙连接对孤立的血管组织中收缩反应的贡献。对已知包含间隙连接的分离制剂的研究表明，α（1）-肾上腺素能受体介导的各种分离的血管组织的收缩反应，通过与研究充分的亲脂性解偶联剂庚醇的细胞间通讯的选择性破坏而显着调节。这些药理研究的解释明确取决于庚醇解偶联作用的选择性。大量实验证据表明，在迄今检查的制剂中，使用的浓度下，庚醇确实确实具有选择性的解偶联作用。实际上，最近的实验为庚烷选择性的操作定义提供了经验支持，并且为间隙连接在调节离体血管组织中的收缩反应中发挥了功能性作用。操作定义仅指出存在一个狭窄的，尽管可识别的浓度范围，在该范围内可以合理地假设庚醇的作用主要与其在间隙连接处的解偶联作用有关。间隙连接的功能性作用是由它们在分离组织收缩过程中对张力发展的必要贡献来定义的。在实验上，这可以可视为在选择性解偶联庚醇浓度存在下，分离的血管组织的收缩反应显着减少。因此，对可用数据的有力解释是，它们为间隙连接在调节分离的血管组织的α（1）-肾上腺能收缩性中的主要作用提供了令人信服的间接证据。 [参考：49]

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