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首页> 外文期刊>Life sciences >Effect of a mu-opioid receptor-selective antagonist on interleukin-6 fever.
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Effect of a mu-opioid receptor-selective antagonist on interleukin-6 fever.

机译：μ阿片受体选择性拮抗剂对白介素6发热的作用。

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The endogenous opioid system has been found to be involved in fever caused by pyrogens. Recent work in our laboratory has demonstrated that the mu-opioid receptor is involved in interleukin-1beta (IL-1beta)- and in lipopolysaccharide (LPS)-induced fevers. In the present study, we have investigated the role of the mu-opioid receptor in the preoptic anterior hypothalamus (POAH) in fever induced by interleukin-6 (IL-6). Following stereotaxic implantation of a guide cannula into the POAH for microinjection, radio transmitters to monitor body temperature (Tb) continuously were inserted intraperitoneally. Adult male Sprague-Dawley rats were microinjected with 0.5 microg of the selective mu-opioid receptor antagonist, cyclic D-phe-Cys-Try-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP), into the POAH. Thirty min later, IL-6 (100 ng) was injected into the POAH. CTAP significantly blocked the IL-6 fever. CTAP alone had no effect on Tb during the 390-min recording period. These data indicate that mu-opioid receptors within the POAH mediate IL-6 fever and add to the increasing evidence that the opioid system is involved in the pathogenesis of fever in rats.
机译：已经发现内源性阿片样物质系统与由热原引起的发烧有关。我们实验室的最新工作表明，μ阿片受体参与白介素-1β（IL-1β）和脂多糖（LPS）引起的发烧。在本研究中，我们已经研究了白细胞介素6（IL-6）引起的发烧前视前下丘脑（POAH）中的阿片受体的作用。在将引导套管立体定位植入POAH中进行显微注射之后，将连续监测体温（Tb）的无线电发射器腹膜内插入。成年雄性Sprague-Dawley大鼠被微量注射0.5微克选择性mu阿片受体拮抗剂，环状D-phe-Cys-Try-D-Trp-Arg-Thr-Pen-Thr-NH2（CTAP）。三十分钟后，将IL-6（100 ng）注入POAH。 CTAP显着阻断了IL-6发烧。在390分钟的记录期间内，仅CTAP不会对Tb产生影响。这些数据表明，POAH中的μ阿片受体介导了IL-6发烧，并增加了越来越多的证据表明阿片系统参与大鼠发烧的发病机理。

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