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首页> 外文期刊>Cell and Tissue Research >Distribution of peptidergic populations in the human dentate gyrus (somatostatin [SOM-28, SOM-12] and neuropeptide Y [NPY]) during postnatal development.
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Distribution of peptidergic populations in the human dentate gyrus (somatostatin [SOM-28, SOM-12] and neuropeptide Y [NPY]) during postnatal development.

机译：出生后发育过程中人齿状回中肽能种群的分布（生长抑素[SOM-28，SOM-12]和神经肽Y [NPY]）。

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摘要

The postnatal development of the human hippocampal formation establishes the time and place at which we start autobiographical memories. However, data concerning the maturation of the neurochemical phenotypes characteristic of interneurons in the human hippocampus are scarce. We have studied the perinatal and postnatal changes of the dentate gyrus (DG) interneuron populations at three rostrocaudal levels. Immunohistochemically identified neurons and fibers for somatostatin (SOM-12 and SOM-28) and neuropeptide Y (NPY) and the co-localization of SOM-28 and NPY were analyzed. In total, 13 cases were investigated from late pregnancy (1 case), perinatal period (6 cases), first year (1 case), early infancy (3 cases), and late infancy (2 cases). Overall, the pattern of distribution of these peptides in the DG was similar to that of the adult. The distribution of cells was charted, and the cell density (number of positive cells/mm(2)) was calculated. The highest density corresponded to the polymorphic cell layer and was higher at pre- and perinatal periods. At increasing ages, neuron density modifications revealed a decrease from 5 postnatal months onward. In contrast, by late infancy, two immunoreactive bands for SOM-28 and NPY in the molecular layer were much better defined. Double-immunohistochemistry showed that NPY-positive neurons co-localized with SOM-28, whereas some fibers contained only one or other of the neuropeptides. Thus, this peptidergic population, presumably inhibitory, probably has a role in DG maturation and its subsequent functional activity in memory processing.
机译：人类海马结构的出生后发育建立了我们开始自传记忆的时间和地点。然而，关于人类海马中神经元特征性神经化学表型成熟的数据很少。我们已经研究了在三个杆状尾骨水平上齿状回（DG）中神经元群体的围产期和产后变化。免疫组织化学鉴定了生长抑素（SOM-12和SOM-28）和神经肽Y（NPY）的神经元和纤维，以及SOM-28和NPY的共定位。从怀孕后期（1例），围产期（6例），第一年（1例），早期婴儿（3例）和晚期婴儿（2例）总共调查了13例。总体而言，这些肽在DG中的分布方式与成人相似。绘制细胞分布图，并计算细胞密度（阳性细胞数/ mm（2））。最高密度对应于多态性细胞层，并且在产前和围产期较高。随着年龄的增长，神经元密度的改变显示出从出生后5个月开始下降。相反，到婴儿晚期，分子层中的SOM-28和NPY的两个免疫反应条带被更好地定义。双重免疫组织化学显示，NPY阳性神经元与SOM-28共定位，而某些纤维仅包含一种或另一种神经肽。因此，这种肽能种群可能具有抑制作用，可能在DG成熟及其在记忆加工中的后续功能活性中起作用。

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