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首页> 外文期刊>Life sciences >Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model.
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Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model.

机译：姜黄素在戊四氮点燃的癫痫大鼠模型中对癫痫发作和认知障碍的保护作用。

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AIM: Epilepsy as well as chronic use of most antiepileptic drugs predisposes to cognitive impairment. Curcumin has been reported to possess antioxidant, anticonvulsant as well as neuroprotective potential. Hence, this study was conducted to evaluate the effect of curcumin against seizures, cognitive impairment and oxidative stress in pentylenetetrazole-induced kindling in rats. MAIN METHODS: The effect of pretreatment with curcumin (100, 200 and 300 mg/kg, orally) on pentylenetetrazole (PTZ)-induced kindling, kindling-induced cognitive impairment and oxidative stress was evaluated. Male Wistar rats were injected PTZ (30 mg/kg, i.p.) once every alternate day (48+/-1h) until the development of kindling. Cognitive impairment was assessed using elevated plus maze and passive avoidance test while the oxidative stress parameters (malondialdehyde and glutathione) were estimated in the whole brain at the end of experiments. KEY FINDINGS: PTZ, 30 mg/kg, induced kindling in rats after 31.0+/-1.4 days. Curcumin showed dose-dependent anti-seizure effect. Curcumin (300 mg/kg) significantly increased the latency to myoclonic jerks, clonic seizures as well as generalized tonic-clonic seizures, improved the seizure score and decreased the number of myoclonic jerks. PTZ kindling induced a significant oxidative stress and cognitive impairment which was reversed by pretreatment with curcumin in a dose-dependent manner. SIGNIFICANCE: The results indicate that pretreatment with curcumin ameliorates seizures, oxidative stress and cognitive impairment in PTZ induced kindling in rats. These results thus suggest the potential of curcumin as an adjuvant in epilepsy both to prevent seizures as well as to protect against seizure induced memory impairment.
机译：目的：癫痫病以及大多数抗癫痫药的长期使用容易导致认知障碍。据报道姜黄素具有抗氧化，抗惊厥以及神经保护的潜力。因此，本研究旨在评估姜黄素对戊戊四唑诱发的大鼠癫痫发作，认知障碍和氧化应激的影响。主要方法：评估姜黄素（分别为100、200和300 mg / kg口服）对戊四唑（PTZ）引起的点燃，点燃引起的认知障碍和氧化应激的影响。每隔一天（48 +/- 1h）一次对雄性Wistar大鼠进行PTZ（30 mg / kg，腹腔注射）注射，直至点燃。使用高架迷宫和被动回避测试评估认知障碍，同时在实验结束时评估整个大脑的氧化应激参数（丙二醛和谷胱甘肽）。主要发现：31.0 +/- 1.4天后，PTZ 30 mg / kg诱发大鼠点燃。姜黄素具有剂量依赖性的抗癫痫作用。姜黄素（300 mg / kg）显着增加了对肌阵挛性抽搐，阵挛性癫痫发作以及全身性强直-阵挛性癫痫发作的潜伏期，改善了癫痫发作评分并减少了肌阵挛性阵挛的数量。 PTZ点燃会引起明显的氧化应激和认知障碍，姜黄素预处理可以逆转这种氧化应激和认知障碍，且呈剂量依赖性。意义：结果表明，姜黄素预处理可改善癫痫发作，氧化应激和PTZ诱发的大鼠认知障碍。因此，这些结果表明姜黄素作为癫痫佐剂的潜力既可以预防癫痫发作，也可以预防癫痫发作引起的记忆障碍。

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