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首页> 外文期刊>Life sciences >Regional sympathetic activity in pre-hypertensive phase of spontaneously hypertensive rats.
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Regional sympathetic activity in pre-hypertensive phase of spontaneously hypertensive rats.

机译：自发性高血压大鼠高血压前期的区域交感神经活动。

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摘要

Imbalances in central and peripheral sympathetic nervous system (SNS) activity have been observed in essential and experimental hypertension. This study was carried out in order to evaluate SNS activity in two distinct tissue types of spontaneously hypertensive rats (SHR), compared to Wistar-Kyoto normotensive (WKY) rats, in the pre-hypertensive phase (4-5 weeks of age). Interstitial concentrations of norepinephrine (NE) and other catecholamines were measured by microdialysis in striated muscle, whose tone is controlled by baroreflexes, and in the subcutaneous adipose tissue where sympathetic output mainly controls metabolism. Two groups of SHR and WKY male rats were studied, aged 4-5 weeks, with a mean body weight of 92 and 86 g respectively. Systolic blood pressure (SBP, tail-cuff) values were 113 mm Hg (SD +/- 6.2) in SHR and 108 mm Hg (SD +/- 7.3) in WKY rats (p=0.28,t test). Two microdialysis probes were positioned in the subcutaneous fatty tissue and in the striated muscle of the parascapular region and perfused with Ringers' solution. The dialysate was collected every thirty minutes for 3 hours and analyzed in HPLC-ED to determine the content of NE and other catecholamines. Interstitial levels of NE were higher in SH than in WKY rats in both tissues. Mean NE values from subcutaneous adipose tissue in 4-5 week-old SHR were 1162 +/- 193 pg/ml compared to 496 + 188 pg/ml in WKY rats (p<0.001, t test). Muscle tissue NE levels in SHR were 1241 +/- 337 pg/ml vs. 521 +/- 138 pg/ml in WKY rats (p<0.001, t test). Plasma NE concentrations (279 +/- 61 pg/ml in SHR vs 246 + 69 pg/ml in WKY P = 0.65, t test) were not significantly different between the two strains at this young age. These findings suggest SNS hyperactivity in young SHR, though still normotensive, possibly dissociated from regional components of regulation (baroreceptor control in striated muscle and metabolic control in subcutaneous adipose tissue).
机译：在原发性和实验性高血压中已观察到中枢和周围交感神经系统（SNS）活动的失衡。进行这项研究是为了评估在高血压前期（4-5周龄），与Wistar-Kyoto正常血压（WKY）大鼠相比，自发性高血压大鼠（SHR）的两种不同组织类型的SNS活性。肾上腺素（NE）和其他儿茶酚胺的间质浓度通过微渗析法在横纹肌中进行测定，横纹肌的音调受压力反射控制，而在皮下脂肪组织中交感神经输出主要控制新陈代谢。研究了两组SHR和WKY雄性大鼠，年龄为4-5周，平均体重分别为92和86 g。 SHR的收缩压（SBP，尾袖）值为113 mm Hg（SD +/- 6.2），WKY大鼠的收缩压为108 mm Hg（SD +/- 7.3）（p = 0.28，t检验）。将两个微透析探针置于皮下脂肪组织和肩cap旁区域的横纹肌中，并用林格氏液灌注。每三十分钟收集一次透析液，持续3小时，并在HPLC-ED中进行分析，以确定NE和其他儿茶酚胺的含量。在两个组织中，SH中NE的间质水平均高于WKY大鼠。在4-5周龄SHR中，皮下脂肪组织的平均NE值为1162 +/- 193 pg / ml，而WKY大鼠为496 + 188 pg / ml（p <0.001，t检验）。 SHR中的肌肉组织NE水平为1241 +/- 337 pg / ml，而WKY大鼠为521 +/- 138 pg / ml（p <0.001，t检验）。在这个年轻人中，这两种菌株的血浆NE浓度（SHR中为279 +/- 61 pg / ml，而WKY P中为246 + 69 pg / ml，t检验）无显着差异。这些发现表明，年轻的SHR患者SNS亢进，尽管仍是正常血压，但可能与调节的区域成分（横纹肌的压力感受器控制和皮下脂肪组织的代谢控制）分离。

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