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首页> 外文期刊>Life sciences >Interleukin-1 beta inhibits the intestinal transport of (14C) 3-O-methylglucose in the rat.
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Interleukin-1 beta inhibits the intestinal transport of (14C) 3-O-methylglucose in the rat.

机译：白介素-1β抑制大鼠中（14C）3-O-甲基葡萄糖的肠道转运。

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摘要

Interleukin-1 (IL-1) is known to be a hypoglycemic cytokine, but its mechanism of action is still unknown. Since the blood glucose levels depend on the amount of glucose entering and leaving the circulation, this work was conducted to test the hypothesis that the hypoglycemia observed with IL-1beta might result, at least partially, from a reduced intestinal glucose absorption. Male Sprague Dawley rats were injected intraperitoneally (i.p.) with IL-1beta, and a jejunal segment was perfused with [14C] 3-O-methylglucose for 5, 15, 25 and 40 min. Our results showed that IL-1beta significantly inhibited the mucosal uptake of this hexose and reduced its intestinal retention. The time course and the dose response effect for this cytokine were also determined. Studies on the effect of IL-1beta on the activity of the intestinal Na+-K+ ATPase demonstrated a significant inhibition of the pump. The effect of IL-1beta on the hexose transport across the brush border membrane may thus be attributed to its inhibitory effect on the Na+-K+ ATPase.
机译：已知白介素-1（IL-1）是一种降血糖细胞因子，但其作用机理仍然未知。由于血糖水平取决于进入和离开循环系统的葡萄糖量，因此进行了这项工作以检验以下假设：用IL-1β观察到的低血糖症可能至少部分是由于肠道葡萄糖吸收减少所致。向雄性Sprague Dawley大鼠腹膜内（i.p.）注射IL-1beta，并向空肠段注入[14C] 3-O-甲基葡萄糖5、15、25和40分钟。我们的结果表明，IL-1β显着抑制了该己糖的粘膜摄取，并减少了其肠道保留。还确定了该细胞因子的时间进程和剂量反应效果。关于IL-1β对肠道Na + -K + ATPase活性的影响的研究表明，该泵具有明显的抑制作用。因此，IL-1β对己糖跨刷缘膜转运的影响可能归因于其对Na + -K + ATPase的抑制作用。

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