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alpha(1)-adrenoceptor subtypes and two receptor systems in vascular tissues

机译：血管组织中的alpha（1）-肾上腺素受体亚型和两个受体系统

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The subtypes of alpha(1)-adrenoceptor are coexpressed in many tissues. We examined the relationship between coexpressed alpha(1)-adrenoceptor subtypes and their functions in blood vessels. Rat and rabbit aortas coexpressed three subtypes (alpha(1A), alpha(1B), alpha(1D)) and four subtypes (alpha(1A), alpha(1B), alpha(1D), alpha(1L)), respectively. In rat aorta however, noradrenaline-induced contraction was mediated predominantly through the alpha(1D) subtype, and oxymetazoline produced alpha(1B)-mediated contraction. In rabbit aorta, concentration-response curves for noradrenaline were composed of two components (alpha(1B) and alpha(1L)-mediated), while oxymetazoline produced alpha(1L)-mediated contraction. Therefore, the inhibitory actions of some antagonists varied markedly among tissues and agonists. These results demonstrate diversity of the two receptor systems and suggest that the heterogeneity of physiological responses reflects the differences in functional subtypes among tissues and in their sensitivities to agonists and antagonists. [References: 9]
机译：alpha（1）-肾上腺素受体的亚型在许多组织中共表达。我们检查了共表达的alpha（1）-肾上腺素受体亚型与其在血管中的功能之间的关系。大鼠和兔主动脉分别共表达三种亚型（alpha（1A），alpha（1B），alpha（1D））和四种亚型（alpha（1A），alpha（1B），alpha（1D），alpha（1L））。然而，在大鼠主动脉中，去甲肾上腺素引起的收缩主要通过α（1D）亚型介导，羟甲唑啉产生α（1B）介导的收缩。在兔主动脉中，去甲肾上腺素的浓度-响应曲线由两个成分（α（1B）和α（1L）介导）组成，而羟甲唑啉产生α（1L）介导的收缩。因此，一些拮抗剂的抑制作用在组织和激动剂之间明显不同。这些结果证明了两种受体系统的多样性，并表明生理反应的异质性反映了组织之间功能亚型的差异以及它们对激动剂和拮抗剂的敏感性。 [参考：9]

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