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首页> 外文期刊>Life sciences >Blockade of cocaine-induced conditioned place preference: relevance to cocaine abuse therapeutics.
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Blockade of cocaine-induced conditioned place preference: relevance to cocaine abuse therapeutics.

机译：可卡因诱发的条件障碍的封锁：与可卡因滥用疗法的相关性。

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摘要

Conditioned place preference/aversion testing is a behavioral method believed capable of measuring the affective (positive, neutral or negative) properties of psychoactive drugs. Cocaine injections in rats reliably produces a positive place preference. Drugs that attenuate or block this effect of cocaine have obvious potential for developing treatments to address cocaine addiction as well as to add to the scientific understanding of the mechanism of cocaine's action at the cellular level. To date, six drugs have been reported to block the expression of a cocaine-induced conditioned place preference (CPP) and this review evidences the cocaine-induced CPP blockage by the two potent L-type calcium channel blockers, isradipine and nifedipine, the two serotonin-3 receptor antagonists, MDL72222 and ICS205-930, the delta opioid receptor selective antagonist naltrindole, and lastly, a mixed opioid agonist-antagonist buprenorphine. Additional evidence relating to the blockade of other cocaine behavioral effectsby these putative blockers is addressed, where appropriate, from studies employing other procedures such as drug stimulus discrimination, self-administration, electrical brain stimulation and increases in locomotor activity. The significance of these findings is discussed in the context of their relevance to the development of treatment regimens to allow for cessation of cocaine abuse.
机译：条件性场所偏爱/厌恶测试是一种行为方法，被认为能够测量精神活性药物的情感（阳性，中性或阴性）特性。在大鼠中注射可卡因确实可以产生积极的位置偏好。减弱或阻止可卡因这种作用的药物具有开发治疗可卡因成瘾以及增加对可卡因在细胞水平上作用机理的科学理解的明显潜力。迄今为止，已经报道了六种药物可阻断可卡因诱导的条件性位置偏爱（CPP）的表达，并且该综述证明了两种有效的L型钙通道阻断剂伊沙地平和硝苯地平可卡因诱导的CPP阻断，这两种血清素3受体拮抗剂MDL72222和ICS205-930，δ阿片受体选择性拮抗剂naltrindole，最后是混合的阿片激动剂-拮抗剂丁丙诺啡。在适当的情况下，可以通过采用其他程序（例如药物刺激识别，自我管理，脑电刺激和运动能力增加）的研究来探讨与这些假定的阻断剂阻断其他可卡因行为效应有关的其他证据。这些发现的意义将在其与允许停止可卡因滥用的治疗方案发展的相关性的背景下进行讨论。

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