CANNABINOID PHOTOLABELLING OF A G-PROTEIN GAMMA-SUBUNIT IN MOUSE PERITONEAL CELLS

Burstein SH.; Subramanian A.; Debatis M.

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CANNABINOID PHOTOLABELLING OF A G-PROTEIN GAMMA-SUBUNIT IN MOUSE PERITONEAL CELLS

机译：G蛋白γ-亚基在小鼠腹膜细胞中的大麻素光化作用

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Binding and photoactivation of a cannabinoid-derived ligand to intact mouse peritoneal cells has resulted in the labelling of a G-protein gamma-subunit. The assignment of structure is based on the product's physical characteristics and its ability to react with a polyclonal antiserum raised against the partial amino acid sequence for a gamma-subunit expressed in spleen cells. The binding characteristics of the ligand to the cells suggests that this gamma-subunit, and its associated alpha, and beta subunits, are located in close proximity to one of the transmembrane cannabinoid receptors. Our findings further suggest a possible experimental approach to identifying receptor-G-protein complexes in intact cells. [References: 15]

机译：大麻素衍生的配体与完整小鼠腹膜细胞的结合和光活化已导致标记G蛋白γ亚基。结构的确定基于产品的物理特性及其与针对脾细胞中表达的γ-亚基的部分氨基酸序列产生的多克隆抗血清反应的能力。配体与细胞的结合特征表明，该γ亚基及其相关的α和β亚基紧邻跨膜大麻素受体之一。我们的发现进一步提示了鉴定完整细胞中受体-G-蛋白复合物的可能的实验方法。 [参考：15]

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《Life sciences》 |1995年第24期|共8页
作者
Burstein SH.; Subramanian A.; Debatis M.;
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正文语种 eng
中图分类生命的起源;生命科学总论;
关键词
G-protein gamma-subunit; Photoaffinity cannabinoid ligand; Peritoneal cells; Gamma-subunit antiserum; Receptor; Existence; Brain; Cdna;

机译：G蛋白γ亚基;光亲和性大麻素配体;腹膜细胞;γ亚基抗血清;受体;存在;脑;Cdna;

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1. 恒河猴CGβ亚基(rmCGβ)DNA在HeLa细胞中的表达及其对小鼠免疫反应的诱导 [J] . 陈云, 刘喆, 彭景, 动物学报（英文版） . 2001,第004期
2. CANNABINOID PHOTOLABELLING OF A G-PROTEIN GAMMA-SUBUNIT IN MOUSE PERITONEAL CELLS [J] . Burstein SH., Subramanian A., Debatis M. Life sciences . 1995,第23a24期

机译：G蛋白γ-亚基在小鼠腹膜细胞中的大麻素光化作用
3. Cannabinoid signaling in rat cerebellar granule cells: G-protein activation, inhibition of glutamate release and endogenous cannabinoids. [J] . Breivogel CS, Walker JM, Huang SM, Neuropharmacology . 2004,第1期

机译：大鼠小脑颗粒细胞中的大麻素信号传导：G蛋白活化，谷氨酸释放抑制和内源性大麻素。
4. Divergent Response to Cannabinoid Receptor Stimulation in High and Low Stress-Induced Analgesia Mouse Lines Is Associated with Differential G-Protein Activation [J] . Lesniak Anna, Chmielewska Diana, Poznanski Piotr, Neuroscience: An International Journal under the Editorial Direction of IBRO . 2019,第期

机译：对高和低应激诱导的镇痛小鼠线中大麻素受体刺激的发散反应与差异G蛋白激活有关
5. Effect of Polysaccharides from Fresh Persimmon (Diospyros kaki) Fruits and its Sulfated Derivates on the Immunomodulatory Activity of Mouse Peritoneal Macrophage Cells [C] . Yan Ding, Yali Zhang, Hui Guo BMNA2012 . 2013

机译：多糖从新鲜柿子（Diospyros Kaki）果实的影响及其硫酸化衍生物对小鼠腹膜巨噬细胞免疫调节活性的影响
6. NMR and computer modeling studies of G-protein coupled cannabinoid receptors and bioactive cannabinoid ligands. [D] . Chen, Jianzhong. 2005

机译：G蛋白偶联大麻素受体和生物活性大麻素配体的NMR和计算机建模研究。
7. Inhibition of subunit dissociation and release of the stimulatory G-protein Gs by beta gamma-subunits and somatostatin in S49 lymphoma cell membranes. [O] . L A Ransnäs, D Leiber, P A Insel 1991

机译：βγ亚基和生长抑素在S49淋巴瘤细胞膜中抑制亚基解离并释放刺激性G蛋白Gs。
8. Stepwise activation of the mouse acetylcholine receptor delta- and gamma-subunit genes in clonal cell lines. [O] . Crowder, C M, Merlie, J P 1988

机译：在克隆细胞系中逐步激活小鼠乙酰胆碱受体δ-和γ-亚基基因。
9. Effect of Mouse Type I Interferon on Mouse Bone Marrow Cells and Peritoneal Exudate Cells Cultured in vitro [R] . Hale, M. L., McCarthy, K. F. 1981

机译：小鼠I型干扰素对体外培养的小鼠骨髓细胞和腹膜渗出细胞的影响

CANNABINOID PHOTOLABELLING OF A G-PROTEIN GAMMA-SUBUNIT IN MOUSE PERITONEAL CELLS

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