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首页> 外文期刊>Life sciences >Differential effect of chronic antidepressant treatments on lipopolysaccharide-induced depressive-like behavioural symptoms in the rat
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Differential effect of chronic antidepressant treatments on lipopolysaccharide-induced depressive-like behavioural symptoms in the rat

机译：慢性抗抑郁药对大鼠脂多糖诱导的抑郁样行为症状的差异作用

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In the present study we observed that lipopolysaccharide (LPS) administration provoked a characteristic reduction in body weight gain, food consumption, saccharin (but not water) consumption and nocturnal locomotor activity. It has been previously suggested that the ability of LPS to suppress the consumption of, and preference for, a palatable solution such as saccharin without altering water consumption, may represent an anhedonic response. The results of the present study demonstrate that chronic treatment with the tricyclic antidepressant (TCA) desipramine (7.5 mg/kg; i. p.) prevented LPS-induced anorexia, loss of body weight, the antidipsogenic effect and hypoactivity. In contrast, chronic treatment with the antidepressants paroxetine (7.5 mg/kg; i. p.) and venlafaxine (10 mg/kg; i. p.) failed to alter any of the LPS-induced behavioural responses. Furthermore, chronic treatment with desipramine (and to a lesser extent paroxetine) reduced the consumption of, and preference for, saccharin suggesting that these antidepressant treatments induce an "anhedonic" response in their own right. In conclusion, chronic desipramine treatment attenuated LPS-induced depressive-like behavioural symptoms in the rat. However, chronic treatment with paroxetine and venlafaxine did not significantly alter LPS-induced behavioural responses. The results of the present study support the hypothesis that TCA's may exert part of their anti-depressive efficacy through their effects on the immune system. However, this property does not appear to be shared by newer antidepressants which possess a better side effect profile than the TCA's. The suppressive effect of TCA's on proinflammatory cytokine secretion is discussed as a mechanism by which these agents alter LPS-induced behavioural responses.
机译：在本研究中，我们观察到脂多糖（LPS）的使用引起了体重增加，食物消耗，糖精（而非水）消耗和夜间运动功能的特征性降低。先前已经提出，LPS在不改变水消耗的情况下抑制诸如糖精之类的可口溶液的消耗以及对其的偏爱的能力可能代表无性反应。本研究的结果表明，用三环抗抑郁药（TCA）地昔帕明（7.5 mg / kg; i。p。）进行长期治疗可防止LPS引起的厌食症，体重减轻，抗血脂作用和功能减退。相反，用抗抑郁药帕罗西汀（7.5 mg / kg;腹腔注射）和文拉法辛（10 mg / kg;腹腔注射）进行的慢性治疗未能改变LPS诱导的任何行为反应。此外，用地昔帕明（和较小程度的帕罗西汀）进行长期治疗减少了糖精的消耗，并降低了对糖精的偏好，表明这些抗抑郁药本身就可引起“麻醉性”反应。总之，长期地昔帕明治疗可减轻LPS诱导的大鼠抑郁样行为症状。然而，帕罗西汀和文拉法辛的慢性治疗并未显着改变LPS诱导的行为反应。本研究的结果支持以下假设：TCA可能通过其对免疫系统的作用而发挥其部分抗抑郁功效。但是，这种特性似乎不被较之TCA具有更好副作用的新型抗抑郁药所共有。 TCA对促炎细胞因子分泌的抑制作用被讨论为一种机制，通过这些机制这些药剂可以改变LPS诱导的行为反应。

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