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首页> 外文期刊>Life sciences >Lack of effect of flurothyl, a non-anesthetic fluorinated ether, on rat brain synaptic plasma membrane calcium-ATPase.
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Lack of effect of flurothyl, a non-anesthetic fluorinated ether, on rat brain synaptic plasma membrane calcium-ATPase.

机译：氟噻吩（非麻醉性的氟化醚）对大鼠脑突触质膜钙ATPase的作用缺乏。

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摘要

Plasma membrane Ca2+-ATPase (PMCA), a regulator of intracellular calcium, is inhibited by volatile anesthetics and by xenon and nitrous oxide. Response of a cellular system to anesthetics, particularly to volatile agents, raises the question of non-specific, even toxic, side effects unrelated to anesthetic action. Compounds with chemical and physical properties similar to halogenated anesthetics, but which lack anesthetic effect, have been used to address this question. We have compared the effects of halothane and flurothyl, a non-anesthetic fluorinated ether, on PMCA Ca2+ transport across isolated brain synaptic plasma membranes (SPM). Flurothyl, at concentrations predicted by the Meyer-Overton curve to range from 0.4 to 2.6 MAC (minimum alveolar concentration), had no significant on PMCA activity. In contrast halothane, 1.3 MAC, reduced Ca2+ transport 30 to 40%. These findings provide further evidence for a specific effect of inhalation anesthetics on neuronal plasma membrane Ca2+-ATPase.
机译：质膜Ca2 + -ATPase（PMCA）是细胞内钙的调节剂，被挥发性麻醉剂以及氙气和一氧化二氮抑制。细胞系统对麻醉药，特别是对挥发性药物的反应，引起了与麻醉药作用无关的非特异性，甚至有毒副作用的问题。具有类似于卤化麻醉剂的化学和物理性质但缺乏麻醉作用的化合物已用于解决该问题。我们已经比较了氟烷和氟噻吩（一种非麻醉性的氟化醚）对跨分离的脑突触质膜（SPM）的PMCA Ca2 +转运的影响。在Meyer-Overton曲线预测的浓度范围为0.4到2.6 MAC（最低肺泡浓度）范围内的氟乙基对PMCA活性无显着影响。相比之下，氟烷1.3 MAC降低了Ca2 +的传输30％至40％。这些发现为吸入麻醉药对神经元质膜Ca2 + -ATPase的特定作用提供了进一步的证据。

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