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首页> 外文期刊>Life sciences >Effect of monochloramine on recovery of gastric mucosal integrity and blood flow response in rat stomachs-relation to capsaicin-sensitive sensory neurons
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Effect of monochloramine on recovery of gastric mucosal integrity and blood flow response in rat stomachs-relation to capsaicin-sensitive sensory neurons

机译：一氯胺对大鼠胃黏膜完整性和血流反应的恢复与辣椒素敏感的感觉神经元的关系

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摘要

Gastric mucosal blood flow (GMBF) response and the recovery of gastric mucosal integrity were investigated in anesthetized rat stomachs after damage by monochloramine (NH2Cl), in comparison with 20 mM taurocholate Na (TC). A rat stomach was mounted in an ex-vivo chamber, and the mucosa was exposed to 50 mM HCl during a test period. Mucosal application of 20 mM TC for 10 min caused a marked reduction of transmucosal potential difference (PD), but the PD recovered rapidly without development of gross lesions 90 min later. In contrast, the exposure of the mucosa to NH2Cl (5 approx 20 mM) produced a concentration-dependent decrease in gastric PD, and the values remained lowered even 90 min after removal of the agent, resulting in severe hemorrhagic damage in the stomach. TC caused a considerable H~+ back-diffusion, followed by an increase in the GMBF. In the mucosa damaged by NH2Cl, such GMBF responses were not observed, except for the temporal increase during the exposure, although similar degrees of H~+ back-diffusion were observed following NH2Cl treatment. In addition, the prior exposure of the mucosa to NH2Cl significantly attenuated gastric hyperemic response induced by capsaicin but not by misoprostol (a PGE_1 derivative) or NOR-3 (a NO donor). Chemical ablation of capsaicin-sensitive sensory neurons had no effect on the PD reduction caused by TC but totally attenuated the GMBF response, resulting in hemorrhagic damage in the stomach. These results suggest that NH2Cl delayed the recovery of the mucosal integrity in the stomach after damage, and this effect may be attributable, at least partly, to the impairment of gastric hyperemic response associated with H~+ back-diffusion, probably due to dysfunction of capsaicin-sensitive sensory neurons.
机译：与20 mM牛磺胆酸钠（TC）相比，在单氯胺（NH2Cl）损伤后麻醉的大鼠胃中研究了胃粘膜血流（GMBF）反应和胃粘膜完整性的恢复。将大鼠胃安装在离体室中，并且在测试期间将粘膜暴露于50 mM HCl中。粘膜应用20 mM TC持续10分钟可显着降低跨粘膜电位差（PD），但PD可在90分钟后迅速恢复而无明显病变。相反，粘膜暴露于NH2Cl（5约20 mM）会导致胃部PD浓度依赖性降低，甚至在去除药剂后90分钟该值仍会降低，从而导致胃部严重出血性损害。 TC引起大量的H〜+反向扩散，随后GMBF增加。在NH 2 Cl损伤的粘膜中，除了在暴露期间的时间增加外，未观察到这种GMBF反应，尽管在NH 2 Cl处理后观察到相似程度的H +背扩散。另外，粘膜先前暴露于NH 2 Cl显着减弱了辣椒素而不是米索前列醇（PGE_1衍生物）或NOR-3（NO供体）诱导的胃充血反应。辣椒素敏感的感觉神经元的化学消融对TC导致的PD降低没有影响，但完全减弱了GMBF反应，从而导致胃出血。这些结果表明，NH2Cl损伤后延迟了胃黏膜完整性的恢复，这种作用可能至少部分归因于与H〜+反向扩散相关的胃充血反应的损害，这可能是由于H +的功能障碍所致。辣椒素敏感的感觉神经元。

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