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首页> 外文期刊>Life sciences >Endocrine and other responses to acute administration of cannabinoid compounds to non-stressed male calves.
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Endocrine and other responses to acute administration of cannabinoid compounds to non-stressed male calves.

机译：对非应激雄性犊牛急性给予大麻素化合物的内分泌和其他反应。

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There is an abundance of cannabinoid (CB) receptors for derivatives of cannabis plants in the brain and throughout the body, and several naturally occurring arachidonic acid derivatives can activate these receptors. The specific objective of this study was to activate these CB receptors in castrated male calves through administration of several CB agonists and to measure immediate changes in concentrations of several serum hormones, respiration rate, and sensitivity to pain. The rationale for the study was that exogenous activation of CB receptors might reveal whether the endogenous CB system (consisting of receptors and endogenous ligands) plays a role in the stress response of animals and specifically whether the activated CB system might be part of a coping mechanism to combat stress. Intravenous administration of three CB agonists (anandamide, methanandamide and WIN 55212-2) to nine castrated male calves under non-stress conditions provoked immediate increases of serum cortisol and respiration rate as well as rapidly caused hypoalgesia to cutaneous pain and thermal stimuli. Although anandamide and methanandamide did not affect serum prolactin, administration of another CB agonist (WIN 55212-2) did increase serum prolactin abruptly. None of the CB agonists affected serum growth hormone. In summary, many of the changes following administration of CB agonists were similar to a stress response in this species, but there were some agonist-specific differences, notably regarding prolactin secretion, as well as differences between calves and observations made in other species. Although CB receptors in calves may be activated by endogenous ligands during exposure to some stressors, the present results are also consistent with this CB system being part of a coping mechanism that helps animals deal with imposed stressors.
机译：在大脑和整个人体中，都有大量的大麻素（CB）受体用于大麻植物的衍生物，几种天然存在的花生四烯酸衍生物可以激活这些受体。这项研究的具体目标是通过施用几种CB激动剂激活去势雄性犊牛中的这些CB受体，并测量几种血清激素的浓度，呼吸速率和对疼痛的敏感性的即时变化。该研究的理由是，CB受体的外源激活可能揭示内源性CB系统（由受体和内源性配体组成）是否在动物的应激反应中起作用，特别是激活的CB系统是否可能是应对机制的一部分对抗压力。在非压力条件下，对九只cast割的雄性小牛静脉内施用三种CB激动剂（阿南酰胺，甲酰胺和WIN 55212-2）会立即引起血清皮质醇和呼吸速率增加，并迅速引起皮肤痛和热刺激的痛觉过敏。尽管阿南酰胺和甲胺并不影响血清催乳素，但给予另一种CB激动剂（WIN 55212-2）确实会突然增加血清催乳素。 CB激动剂均不影响血清生长激素。总之，施用CB激动剂后，许多变化与该物种的应激反应相似，但存在某些激动剂特异性差异，特别是催乳素分泌方面，以及犊牛与其他物种之间观察到的差异。尽管犊牛中的CB受体在暴露于某些应激源时可能会被内源性配体激活，但目前的结果也与该CB系统是帮助动物应对施加的应激源的应对机制的一部分相一致。

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