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首页> 外文期刊>Life sciences >Dexamethasone modulates the activity of the eel branchial Na+/K+ATPase in both chloride and pavement cells.
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Dexamethasone modulates the activity of the eel branchial Na+/K+ATPase in both chloride and pavement cells.

机译：地塞米松调节氯化物和路面细胞中鳗branch分支Na + / K + ATPase的活性。

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摘要

In fish, gills actively accumulate ions in freshwater (FW) with Na+ absorption taking place at the level of pavement cells, and excrete monovalent ions, mainly Na+ and Cl-, through the chloride cells in sea water (SW). The Na+/K+ATPase plays a crucial role in the functionality of osmoregulatory cells and we showed previously that angiotensin II modulates its activity in the eel gill (1). We here show the effects of synthetic steroid dexamethasone (DEX) on the activity of Na+/K+ATPase in both gill pavement and chloride cells from FW- and SW-adapted animals. Results showed that in the chloride cells 100 nM DEX provoked a significant increment in the activity of Na+/K+ATPase in both SW- and FW-adapted animals. This effect was greatest at 2 hours in SW, and at 6 hours in FW. The increment in the activity of the Na+/K+ATPase was dose-dependent in both environmental adaptations. Conversely, in pavement cells from FW-adapted eels 100 nM DEX decremented the activity of Na+/K+ATPase (4-fold reduction after 6 hour incubations), while in SW, DEX increased the enzyme activity of about 25% at 2 hours, and of about 55% at 6 hours. These results are consistent with the different physiological roles that pavement and chloride cells have in the two different adaptive conditions.
机译：在鱼类中，g活泼地在淡水（FW）中积聚离子，并在路面细胞水平上吸收Na +，并通过海水（SW）中的氯化物细胞排泄单价离子，主要是Na +和Cl-。 Na + / K + ATPase在渗透调节细胞的功能中起着至关重要的作用，我们先前已经证明血管紧张素II调节鳗the中的活性（1）。我们在这里显示了合成类固醇地塞米松（DEX）对g路面和FW和SW适应动物的氯化物细胞中Na + / K + ATPase活性的影响。结果表明，在氯化物细胞中，100 nM DEX在适应SW和FW的动物中引起Na + / K + ATPase活性的显着增加。在西南部2小时和FW 6小时，这种效果最大。在两种环境适应中，Na + / K + ATPase活性的增加均与剂量有关。相反，在适应FW的鳗鱼的铺面细胞中，100 nM DEX降低了Na + / K + ATPase的活性（孵育6小时后降低了4倍），而SW在SW中，DEX在2小时时将酶活性提高了约25％，在6小时时约为55％。这些结果与路面和氯化物细胞在两种不同适应条件下所具有的不同生理作用相一致。

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