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首页> 外文期刊>Life sciences >Increased prostacyclin synthesis by atherosclerotic arteries from estrogen-treated monkeys
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Increased prostacyclin synthesis by atherosclerotic arteries from estrogen-treated monkeys

机译：雌激素治疗的猴子的动脉粥样硬化动脉增加前列环素的合成

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We hypothesized that the atheroinhibitory and cardioprotective effects of estrogen may be mediated in part through increased prostacyclin formation by the artery wall. Atherosclerotic abdominal aorta was collected at necropsy from ovariectomized female monkeys fed an atherogenic diet alone or with added Premarin(R). Basal and arachidonate-stimulated prostacyclin and thromboxane synthesis by artery segments was measured by radioimmunoassay. In contrast to no observed differences in basal release of prostacyclin by the control and estrogen-treated arteries, there was a marked increase (similar to 165%) in arachidonate-stimulated formation of prostacyclin by estrogen-treated arteries, and pros tacyclin synthesis was inversely correlated with plaque size. No differences were observed in basal or arachidonate-stimulated thromboxane synthesis by the control and estrogen-treated arteries. In light of known antiatherogenic and vasodilatory effects of estrogen, increased prostacyclin synthesis by estrogen-treated arteries may, in part, explain estrogen's beneficial effects on the artery wall. (C) 2001 Elsevier Science Inc. All rights reserved. [References: 37]
机译：我们假设雌激素的抗动脉粥样硬化和心脏保护作用可能部分通过动脉壁前列环素形成的增加而介导。尸检时，从单独喂食有动脉粥样化饮食或添加了Premarin的去卵巢的雌性猴子的尸体解剖中收集动脉粥样硬化的腹主动脉。通过放射免疫测定法测量了基础和花生四烯酸酯刺激的前列环素和血栓烷的动脉合成。与对照和雌激素处理的动脉在前列腺素的基础释放中未观察到差异相比，花生四烯酸盐刺激的雌激素处理的动脉前列环素刺激的前列腺素的形成显着增加（约165％），而前列腺环素的合成相反与斑块大小相关。对照和经雌激素处理的动脉在基础或花生四烯酸酯刺激的血栓烷合成中未观察到差异。根据已知的雌激素的抗动脉粥样硬化作用和血管舒张作用，雌激素治疗的动脉增加的前列环素合成可能部分解释了雌激素对动脉壁的有益作用。 （C）2001 Elsevier Science Inc.保留所有权利。 [参考：37]

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