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首页> 外文期刊>Life sciences >Ruthenium red-sensitive cation channels, but not calcitonin gene-related peptide or substance P-mediated mechanisms, protect duodenal villi against acid-induced damage.
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Ruthenium red-sensitive cation channels, but not calcitonin gene-related peptide or substance P-mediated mechanisms, protect duodenal villi against acid-induced damage.

机译：钌红敏感阳离子通道，而不是降钙素基因相关肽或P物质介导的机制，可保护十二指肠绒毛免受酸引起的损害。

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摘要

Intestinal mucosal capsaicin-sensitive afferent nerves mediate, in part, the protective mesenteric hyperemia after intraduodenal acidification. Mechanisms associated the sensory neuropeptides, e.g. calcitonin gene-related peptide (CGRP), substance P, and ruthenium red-sensitive cation channels contribute to acid-induced mesenteric hyperemia, but whether they play a role in protection against acid-induced duodenal villous damage is not known. We tested the hypothesis that in doses that attenuate acid-induced hyperemia, inhibitors of these mechanisms will exacerbate acid-induced duodenal villous damage. Intravenous vehicle, specific receptor antagonists of CGRP (CGRP(8-37)), substance P (CP 96345), intraduodenal ruthenium red or vehicle was administered, followed by intraduodenal perfusion with 0.1 N HCl. Duodenal tissue was processed for hematoxylin and eosin staining. Villous damage was scored by blinded observers. Deep villous injury was significantly increased after treatment with ruthenium red, but not with CGRP(8-37) or CP 96345. These findings support the hypothesis that ruthenium red-sensitive cation channels, but not neuropeptides associated with intestinal mucosal afferent nerves, are involved in the acid-sensing mechanism which mediates the protection against acid-induced duodenal villous damage.
机译：十二指肠内酸化后，肠黏膜对辣椒素敏感的传入神经部分介导了保护性肠系膜充血。与感觉神经肽相关的机制，例如降钙素基因相关肽（CGRP），物质P和对钌敏感的阳离子通道会导致酸引起的肠系膜充血，但是它们是否在防止酸引起的十二指肠绒毛损害中起作用尚不清楚。我们检验了以下假设：在减弱酸诱导的充血的剂量中，这些机制的抑制剂将加剧酸诱导的十二指肠绒毛损害。给予静脉内媒介物，CGRP（CGRP（8-37）），物质P（CP 96345），十二指肠内钌红或媒介物的特异性受体拮抗剂，然后用0.1 N HCl进行十二指肠内灌注。对十二指肠组织进行苏木精和曙红染色。盲目观察者对毛损伤进行了评分。用钌红治疗后，深层绒毛损伤显着增加，但未使用CGRP（8-37）或CP 96345进行治疗。这些发现支持以下假设：钌红敏感阳离子通道，但不涉及与肠粘膜传入神经相关的神经肽在酸敏感机制中发挥着重要作用，它介导了针对酸引起的十二指肠绒毛损害的保护作用。

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