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首页> 外文期刊>Life sciences >ETA endothelin receptors are involved in the ouabain-induced haemodynamic effects in the periaqueductal gray area of rats.
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ETA endothelin receptors are involved in the ouabain-induced haemodynamic effects in the periaqueductal gray area of rats.

机译：ETA内皮素受体参与哇巴因诱导的大鼠导水管周围灰色区域的血流动力学作用。

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摘要

The aim of the present study was to asses the effects on blood pressure and vascular resistances elicited by microinjections of ouabain (OUA) within the periaqueductal gray area (PAG). We also tested whether peripheral vascular responses caused by exogenous intra-PAG ouabain involve activation of the PAG-endothelin system.In normotensive Sprague-Dawley rats the basal mean arterial blood pressure (MABP) was 114 +/- 3 mmHg. This was significantly increased by OUA (3 micro g, 122 +/- 2 mmHg, p < 0.05; and 6 micro g, 139 +/- 3 mmHg, p < 0.01) microinjected into the PAG area. Increases in MABP were associated with increases in total peripheral resistances (TPR), organ vascular resistances, and with reduced blood flow of almost all the organs tested: kidneys, skeletal muscle, skin, stomach, spleen, testes and intestine. Cardiac output did not change.Changes in the above vascular parameters induced by OUA were significantly (p < 0.01) reduced by intra-PAG microinjections of FR139317 (a selective ETA receptor antagonist, 5 nmol), SB209670 (a non-selective ETA/ETB receptor antagonist, 3 nmol), but not by BQ 788 (a selective ETB receptor antagonist, 5 nmol).In conclusion, OUA into the PAG area of normotensive rats caused significant changes in peripheral vascular parameters that are reduced by ETA receptor antagonists. These results indicate that PAG-ET-1 system via an action on ETA receptors is involved in the OUA effects.
机译：本研究的目的是评估在导水管周围灰色区域（PAG）内微量注射哇巴因（OUA）对血压和血管阻力的影响。我们还测试了外源性PAG内哇巴因引起的周围血管反应是否涉及PAG内皮素系统的激活。在血压正常的Sprague-Dawley大鼠中，基础平均动脉血压（MABP）为114 +/- 3 mmHg。通过微注射到PAG区域的OUA（3微克，122 +/- 2毫米汞柱，p <0.05; 6微克，139 +/- 3毫米汞柱，p <0.01）显着增加了这种情况。 MABP的增加与总外周阻力（TPR），器官血管阻力的增加以及几乎所有受测器官（肾脏，骨骼肌，皮肤，胃，脾，睾丸和肠）的血流减少有关。心输出量没有变化.PAG内注射FR139317（选择性ETA受体拮抗剂，5 nmol），SB209670（非选择性ETA / ETB）可显着降低OUA引起的上述血管参数的变化（p <0.01）受体拮抗剂3 nmol），但没有被BQ 788（选择性ETB受体拮抗剂5 nmol）所抑制。总之，进入血压正常大鼠PAG区域的OUA引起外周血管参数的显着变化，而这些参数被ETA受体拮抗剂所降低。这些结果表明PAG-ET-1系统通过对ETA受体的作用参与了OUA的作用。

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