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International symposium on cell signaling.

机译：国际细胞信号研讨会。

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摘要

The first and pioneering "International Symposium on Cell Signaling" was held in the beautiful city of Florianopolis in Santa Catarina State, Brazil, from October 28 to 31,2010 at IL Campanario Villaggio Resort on Jurere International Beach. This special issue of Life Sciences focuses on the invited speakers' contributions to the discussion of molecular and structural biology, molecular toxicology and signaling transduction.The field of structural molecular biology has grown steadily in the last 10 years due to enormous advances in protein structure determination techniques, such as X-ray diffraction, nuclear magnetic resonance and biophysical analysis of protein-ligand interaction (using circular dichroism, fluorescence and surface plasmon resonance). Several Nobel prizes in the past decade were awarded in protein structure-related subjects, emphasizing the impact of structural biology on general science. We are now awaiting the discovery of new drugs, therapies and metabolic and signal transduction pathways, based on our increasing knowledge and expansion of the protein folding universe.Living organisms might be exposed to a myriad of potentially toxic substances (e.g., environmental pollutants, medicines, abused drugs), whose effects are diverse and may range from no evident outcomes to significant toxicity, culminating in the occurrence of disease and, eventually, death.
机译：2010年10月28日至31日，在美丽的巴西圣卡塔琳娜州弗洛里亚诺波利斯市举行了首届具有开创性的“细胞信号国际研讨会”，该展览会在尤里国际海滩IL Campanario Villaggio度假村举行。本期生命科学专刊聚焦于受邀演讲者对分子和结构生物学，分子毒理学和信号转导的讨论所做出的贡献。近十年来，由于蛋白质结构测定的巨大进步，结构分子生物学领域稳步增长技术，例如X射线衍射，核磁共振和蛋白质-配体相互作用的生物物理分析（使用圆二色性，荧光和表面等离振子共振）。在过去的十年中，与蛋白质结构相关的学科获得了多个诺贝尔奖，强调了结构生物学对普通科学的影响。基于对蛋白质折叠世界的不断了解和扩展，我们现在正在等待新药，疗法以及代谢和信号转导途径的发现。活生物体可能会接触到大量潜在的有毒物质（例如环境污染物，药物） （滥用药物），其影响是多种多样的，其范围从无明显结果到明显的毒性，最终导致疾病的发生并最终导致死亡。

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