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首页> 外文期刊>Life sciences >Essential oils components as a new path to understand ion channel molecular pharmacology.
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Essential oils components as a new path to understand ion channel molecular pharmacology.

机译：精油成分作为了解离子通道分子药理学的新途径。

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摘要

The discovery and development of new drugs targeting voltage-gated ion channels are important for treating a variety of medical conditions and diseases. Ion channels are molecular nanostructures expressed ubiquitously throughout the whole body, and are involved in many basic physiological processes. Over the years, natural products have proven useful in the pharmacological assessment of ion channel structure and function, while also contributing to the identification of lead molecules for drug development. Essential oils are complex chemical mixtures isolated from plants which may possess a large spectrum of biological activities most of them of clinical interest. Among their bioactive constituents, terpenes are small to medium-sized components and belong to different chemical groups. Various reports have drawn our attention to the fact that terpenes are novel compounds targeting voltage-gated ion channels. The purpose of this review is to provide a focused discussion on the molecular interaction between monoterpenes and phenylpropenes with voltage-gated ion channels in different biological scenarios.
机译：针对电压门控离子通道的新药物的发现和开发对于治疗各种医学状况和疾病非常重要。离子通道是在整个人体中普遍表达的分子纳米结构，并参与许多基本的生理过程。多年来，事实证明，天然产物可用于离子通道结构和功能的药理学评估，同时也有助于鉴定用于药物开发的先导分子。香精油是从植物中分离的复杂化学混合物，它们可能具有广泛的生物活性，其中大多数具有临床意义。在它们的生物活性成分中，萜烯是中小型组分，属于不同的化学基团。各种报道引起我们的注意，萜烯是靶向电压门控离子通道的新型化合物。这篇综述的目的是针对在不同生物场景中单萜和苯基丙烯与电压门控离子通道之间的分子相互作用进行重点讨论。

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