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首页> 外文期刊>Life sciences >SPINAL MU, DELTA AND KAPPA OPIOIDS ALTER CHEMICAL, MECHANICAL AND THERMAL SENSITIVITIES IN AMPHIBIANS
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SPINAL MU, DELTA AND KAPPA OPIOIDS ALTER CHEMICAL, MECHANICAL AND THERMAL SENSITIVITIES IN AMPHIBIANS

机译：螺旋藻，三角洲和κ阿片类药物改变两栖类动物的化学，机械和热敏感性

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Previously we demonstrated the use of chemical (topical acetic acid), thermal (radiant heat) and mechanical (von Frey filament) stimuli as quantifiable behavioral response assays in the northern grass frog, Rana pipiens. Furthermore, response thresholds in all of these sensory modalities are significantly elevated by systemic morphine injections, which can be antagonized by naltrexone. The present study employed these three sensory assays to assess changes in chemical, mechanical and thermal sensitivities following spinal administration of mu, delta and kappa opioids. Significant elevations were observed across all three sensory modalities in each subtype category and these effects were abolished by prior systemic administration of naltrexone. However, naltrexone antagonism of morphine produced hyperalgesia in both the mechanical and thermal modalities. The results support other recent work demonstrating that the spinal site for opioid analgesia is present in amphibians and that the thermal, mechanical and acetic acid assays are measures of true nociceptive activity in the amphibian. [References: 16]
机译：以前，我们证明了在北方草蛙（Rana pipiens）中使用化学（局部乙酸），热（辐射热）和机械（von Frey细丝）刺激作为可量化的行为响应测定法。此外，全身性吗啡注射显着提高了所有这些感觉方式中的反应阈值，纳曲酮可以对抗这种反应。本研究采用这三种感​​觉测定法来评估对mu，delta和kappa类阿片进行脊椎给药后化学，机械和热敏感性的变化。在每个亚型类别的所有三种感觉方式中均观察到显着升高，并且通过事先全身性给予纳曲酮消除了这些作用。然而，吗啡的纳曲酮拮抗作用在机械和热学方面均产生痛觉过敏。结果支持了其他最新研究，这些研究表明两栖动物中存在阿片类药物镇痛的脊髓部位，并且热，机械和乙酸测定法是两栖动物中真正伤害感受活性的量度。 [参考：16]

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