STREPTOZOTOCIN-INDUCED DIABETES PROVOKES CHANGES IN SEROTONIN CONCENTRATION AND ON 5-HT1A AND 5-HT2 RECEPTORS IN THE RAT BRAIN

Sandrini M.; Vergoni AV.; Ottani A.; Bertolini A.; Vitale G.

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STREPTOZOTOCIN-INDUCED DIABETES PROVOKES CHANGES IN SEROTONIN CONCENTRATION AND ON 5-HT1A AND 5-HT2 RECEPTORS IN THE RAT BRAIN

机译：链脲佐菌素诱导的糖尿病可引起大鼠脑内血清素浓度以及5-HT1A和5-HT2受体的改变

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Since reduced levels of brain serotonin are known to cause behavioural abnormalities, to which diabetics are also prone, we investigated the effect, in rats, of chronic diabetes on brain serotonin concentration and on the numbers of 5-HT1A and 5-HT2 receptors in cerebral cortex and brainstem. Our data show that streptozotocin induces a longlasting hyperglicemia that is associated with a decrease in cerebral concentration of serotonin and with an accompanying increase in the maximum number of 5-HT1A and 5-HT2 receptors in the brain areas studied. Our results may suggest that changes in serotonergic transmission in the CNS play a role in diabetes-related behavioural abnormalities. [References: 26]

机译：由于已知降低的血清素水平会导致行为异常，糖尿病患者也容易发生这种异常，因此我们在大鼠中研究了慢性糖尿病对大脑血清素浓度以及大脑中5-HT1A和5-HT2受体数量的影响。皮质和脑干。我们的数据表明，链脲佐菌素诱导了长期的高血糖血症，这与5-羟色胺的大脑浓度降低以及所研究的大脑区域中5-HT1A和5-HT2受体的最大数量随之增加有关。我们的结果可能表明中枢神经系统中血清素能传递的变化在糖尿病相关行为异常中起作用。 [参考：26]

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《Life sciences》 |1997年第16期|共5页
作者
Sandrini M.; Vergoni AV.; Ottani A.; Bertolini A.; Vitale G.;
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正文语种 eng
中图分类生命的起源;生命科学总论;
关键词
Streptozotocin; Diabetes; Serotonin; 5-ht1a receptor; 5-ht2 receptor; Mellitus; Stress;

机译：链脲佐菌素;糖尿病;5-羟色胺;5-ht1a受体;5-ht2受体;妊娠;压力;

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专利

1. STREPTOZOTOCIN-INDUCED DIABETES PROVOKES CHANGES IN SEROTONIN CONCENTRATION AND ON 5-HT1A AND 5-HT2 RECEPTORS IN THE RAT BRAIN [J] . Sandrini M., Vergoni AV., Ottani A., Life sciences . 1997,第16期

机译：链脲佐菌素诱导的糖尿病可引起大鼠脑内血清素浓度以及5-HT1A和5-HT2受体的改变
2. Serotonin modifies the spontaneous spiking activity of gracile nucleus neurons in rats: role of 5-HT1A and 5-HT2 receptors [J] . Grasso C., Volsi G. Li, Barresi M. Archives Italiennes de Biologie . 2016,第2a3期

机译：血清素在大鼠中改变闪烁的胆汁神经元的自发尖峰活动：5-HT1A和5-HT2受体的作用
3. Effects of 5-HT1A receptor antagonists on fluoxetine-induced changes in extracellular serotonin concentrations in rat frontal cortex. [J] . Dawson LA, Nguyen HQ European Journal of Pharmacology: An International Journal . 1998,第1期

机译：5-HT1A受体拮抗剂对氟西汀诱导的大鼠额叶皮质细胞外血清素浓度变化的影响。
4. Mn nanoparticles exacerbates concussive head injury induced blood-brain barrier disruption, brain pathology, and sensory motor dysfunctions. Neuroproetction by Nanowired delivery of 5-HT2 receptor antagonists Ketanserin and Ritanserin [C] . Aruna Sharma, Lianyuan Feng, Dafin F Muresanu, National SBIR/STTR conference;Annual nanotech conference and expo;Annual TechConnect world innovation conference expo . 2015

机译：锰纳米颗粒加剧脑震荡引起的脑血栓屏障破坏，脑病理和感觉运动功能障碍。通过纳米线传递5-HT2受体拮抗剂Ketanserin和Ritanserin进行神经保护
5. In vitro and in vivo pharmacology of novel phenylaminotetralin (PAT) analogs at serotonin 5-HT2 receptors: Development of drugs for neuropsychiatric disorders. [D] . Kondabolu, Krishnakanth. 2013

机译：在血清素5-HT2受体上的新型苯氨基四氢萘（PAT）类似物的体外和体内药理学：神经精神疾病药物的开发。
6. Responsiveness of 5-HT1A and 5-HT2 receptors in the rat orbitofrontal cortex after long-term serotonin reuptake inhibition [O] . Mostafa El Mansari, Pierre Blier 2005

机译：长期血清素再摄取抑制后大鼠眶额皮质中5-HT1A和5-HT2受体的反应性
7. Effects of repeated treatment with fluoxetine and citalopram, 5-HT uptake inhibitors, on 5-HT1A and 5-HT2 receptors in the rat brain. [O] . Klimek V, Zak-Knapik J, Mackowiak M 1994

机译：氟西汀和西酞普兰（5-HT摄取抑制剂）的重复治疗对大鼠大脑中5-HT1A和5-HT2受体的影响。

STREPTOZOTOCIN-INDUCED DIABETES PROVOKES CHANGES IN SEROTONIN CONCENTRATION AND ON 5-HT1A AND 5-HT2 RECEPTORS IN THE RAT BRAIN

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