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首页> 外文期刊>Life sciences >A new spontaneous animal model of NIDDM without obesity in the musk shrew.
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A new spontaneous animal model of NIDDM without obesity in the musk shrew.

机译：NIDDM的一种新的自发动物模型，麝香中没有肥胖。

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The EDS (early-onset diabetes in suncus) colony has been developed as a new closed breeding colony of the musk shrew (Suncus murinus, Insectivora) exhibiting a high incidence of spontaneous diabetes mellitus. We investigated the characteristic features of diabetic shrews in this colony. All diabetic shrews are characterized by glycosuria (Tes-tape value > or = 3+), hyperglycemia (23.3 +/- 0.8 mmol/l) and polyuria, and they were affected by the age of 3 months. Cumulative incidence (64.1% in males and 27.8% in females) was kept intact after the age of 3 months. The growth pattern of diabetic shrews was similar to that of non-diabetic shrews, and obesity was not consistent in diabetic shrews. The intraperioneal glucose tolerance test revealed both impaired glucose tolerance and impaired insulin secretion in diabetic shrews. Insulin sensitivity of diabetic shrews decreased in the intraperioneal insulin tolerance test. Neither severe hypertrophy nor lymphocytic infiltration was observed in pancreatic islets of diabetic shrews. These facts suggested that diabetic shrews in the EDS colony should be classified as early-onset non-insulin dependent diabetes mellitus (NIDDM) without obesity. Early-onset of severe hyperglycemia with impaired glucose tolerance is a distinctive character compared with other non-obese NIDDM models in rodents. We concluded that the diabetic shrews in the EDS colony are a new animal model of human NIDDM without obesity.
机译：EDS（suncus的早发性糖尿病）菌落已被开发为麝香rew（Suncus murinus，Insectivora）的一种新的封闭繁殖菌落，表现出很高的自发性糖尿病发病率。我们研究了该群体中糖尿病sh的特征。所有糖尿病sh均表现为糖尿（Tes-tape值>或= 3+），高血糖症（23.3 +/- 0.8 mmol / l）和多尿症，并且受到3个月大的年龄的影响。 3个月大以后，累计发生率（男性为64.1％，女性为27.8％）保持不变。糖尿病sh的生长方式与非糖尿病sh相似，肥胖在糖尿病sh中并不一致。腹膜内葡萄糖耐量测试显示糖尿病sh体内葡萄糖耐量受损和胰岛素分泌受损。腹膜内胰岛素耐受性试验降低了糖尿病sh的胰岛素敏感性。在糖尿病sh的胰岛中未观察到严重的肥大或淋巴细胞浸润。这些事实表明，EDS菌落中的糖尿病sh应归为无肥胖的早发性非胰岛素依赖型糖尿病（NIDDM）。与其他非肥胖NIDDM模型相比，啮齿类动物的早期高血糖严重发作伴有葡萄糖耐量降低。我们得出的结论是，EDS菌落中的糖尿病sh是没有肥胖的人类NIDDM的新动物模型。

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