首页> 外文期刊>Life sciences >Endogenous catecholamine synthesis, metabolism, storage and uptake in human neutrophils.
【24h】

Endogenous catecholamine synthesis, metabolism, storage and uptake in human neutrophils.

机译:人体中性粒细胞的内源性儿茶酚胺的合成,代谢,储存和摄取。

获取原文
获取原文并翻译 | 示例
           

摘要

Evidence is presented that human neutrophils contain catecholamines and several of their metabolites. In vitro, incubation with alpha-methyl-p-tyrosine or pargyline affects intracellular dopamine, norepinephrine and their metabolites, suggesting catecholamine synthesis and degradation by these cells. Reserpine reduces intracellular dopamine and norepinephrine and desipramine reduces intracellular norepinephrine, suggesting the presence of storage and uptake mechanism. In view of the ability of catecholamines to affect neutrophil function, the present results support the hypothesis that autoregulatory adrenergic mechanisms may exist in these cells.
机译:有证据表明,人类嗜中性粒细胞含有儿茶酚胺及其一些代谢产物。在体外,与α-甲基-对-酪氨酸或Pargyline一起孵育会影响细胞内的多巴胺,去甲肾上腺素及其代谢产物,表明儿茶酚胺的合成和降解。利血平可降低细胞内多巴胺和去甲肾上腺素,而地昔帕明可降低细胞内的去甲肾上腺素,表明存在储存和摄取机制。考虑到儿茶酚胺影响中性粒细胞功能的能力,本结果支持以下假设:这些细胞中可能存在自调节肾上腺素能机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号